ufd-1 Ubiquitin fusion degradation protein 1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ufd-1
Official Full Name: Ubiquitin fusion degradation protein 1 homolog
Primary source: WormBase:WBGene00006733
Locus tag: CELE_F19B6.2
See related: AllianceGenome:WB:WBGene00006733
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in ERAD pathway; embryo development; and positive regulation of protein localization to nucleus. Located in nucleus. Part of VCP-NPL4-UFD1 AAA ATPase complex. Used to study velocardiofacial syndrome. Human ortholog(s) of this gene implicated in DiGeorge syndrome and schizophrenia. Orthologous to human UFD1 (ubiquitin recognition factor in ER associated degradation 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ufd-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (12329408..12330890, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings identified a role for CDC-48(UFD-1/NPL-4) in DNA replication, which is important for cell cycle progression and genome stability.
Title: Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F19B6.2 (e-PCR)
- UniSTS:309830

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of VCP-NPL4-UFD1 AAA ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of VCP-NPL4-UFD1 AAA ATPase complex	IDA Inferred from Direct Assay more info	PubMed
part_of VCP-NPL4-UFD1 AAA ATPase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ubiquitin fusion degradation protein 1 homolog

NP_502348.1

Confirmed by transcript evidence

NP_502349.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

12329408..12330890 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069947.5 → NP_502348.1 Ubiquitin fusion degradation protein 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502348.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19584

Conserved Domains (1) summary

pfam03152
Location:21 → 197

UFD1; Ubiquitin fusion degradation protein UFD1
NM_069948.7 → NP_502349.1 Ubiquitin fusion degradation protein 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502349.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U3I6

Conserved Domains (1) summary

pfam03152
Location:6 → 191

UFD1; Ubiquitin fusion degradation protein UFD1