syx-3 Putative syntaxin-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: syx-3
Official Full Name: Putative syntaxin-3
Primary source: WormBase:WBGene00006371
Locus tag: CELE_F35C8.4
See related: AllianceGenome:WB:WBGene00006371
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in positive regulation of defecation and regulation of muscle contraction. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See syx-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (5349098..5352016)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the syntaxin N-peptide is an initiation factor for the assembly of the SNARE-SM membrane fusion complex.
Title: Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex.
UNC-18 acts as a molecular chaperone for Syntaxin transport in neurons
Title: UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F35C8.4 (e-PCR)
- UniSTS:319305

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane fusion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of defecation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic vesicle docking	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Putative syntaxin-3

NP_001359828.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

5349098..5352016

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373297.3 → NP_001359828.1 Putative syntaxin-3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20024

Conserved Domains (2) summary

cd00179
Location:44 → 193

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

cl22856
Location:204 → 266

SNARE; SNARE motif