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rpn-13 Proteasomal ubiquitin receptor ADRM1;Proteasomal ubiquitin receptor ADRM1 homolog [ Caenorhabditis elegans ]

Gene ID: 3565888, updated on 2-Nov-2024

Summary

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Official Symbol
rpn-13
Official Full Name
Proteasomal ubiquitin receptor ADRM1;Proteasomal ubiquitin receptor ADRM1 homolog
Primary source
WormBase:WBGene00016981
Locus tag
CELE_C56G2.7
See related
AllianceGenome:WB:WBGene00016981
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables ubiquitin-specific protease binding activity. Predicted to be involved in proteasome assembly. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, lid subcomplex. Is expressed in intestine; neurons; and seam cell. Orthologous to human ADRM1 (ADRM1 26S proteasome ubiquitin receptor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rpn-13 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (6340113..6341928, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Very-long-chain 3-oxooacyl-coA reductase let-767 Neighboring gene DUF4604 domain-containing protein Neighboring gene tRNA MethylTransferase Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4. Matilainen O, et al. Cell Rep, 2013 Jun 27. PMID 23770237
  2. The Hippo Pathway Is Essential for Maintenance of Apicobasal Polarity in the Growing Intestine of Caenorhabditis elegans. Lee H, et al. Genetics, 2019 Oct. PMID 31358532, Free PMC Article
  3. DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Lin XX, et al. Nat Commun, 2018 Oct 23. PMID 30353013, Free PMC Article
  4. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article
  5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables endopeptidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-specific protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Proteasomal ubiquitin receptor ADRM1;Proteasomal ubiquitin receptor ADRM1 homolog
NP_001348746.1
  • Confirmed by transcript evidence
NP_498387.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6340113..6341928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001361721.4 → NP_001348746.1  Proteasomal ubiquitin receptor ADRM1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2K5ATW5
    Conserved Domains (2) summary
    cd13314
    Location:19 → 128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:243 → 333
    RPN13_C; UCH-binding domain

  2. NM_065986.10 → NP_498387.2  Proteasomal ubiquitin receptor ADRM1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498387.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09289
    Conserved Domains (2) summary
    cd13314
    Location:19 → 128
    PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13
    pfam16550
    Location:237 → 336
    RPN13_C; UCH-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09289.2

Gene LinkOut

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