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chk-1 Serine/threonine-protein kinase chk-1 [ Caenorhabditis elegans ]

Gene ID: 3565921, updated on 2-Nov-2024

Summary

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Official Symbol
chk-1
Official Full Name
Serine/threonine-protein kinase chk-1
Primary source
WormBase:WBGene00000498
Locus tag
CELE_Y39H10A.7
See related
AllianceGenome:WB:WBGene00000498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone H3T11 kinase activity. Involved in embryo development and mitotic DNA replication checkpoint signaling. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in nucleus. Is expressed in germ line. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See chk-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (3757153..3759469, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Fibronectin type-III domain-containing protein Neighboring gene ncRNA Neighboring gene Myotubularin-related protein 9 Neighboring gene CTLH domain-containing protein;WD_REPEATS_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene Acyltransferase 3 domain-containing protein;Nose resistant-to-fluoxetine protein N-terminal domain-containing protein Neighboring gene Dauer Up-Regulated

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the Caenorhabditis elegans Germline. Hornos Carneiro MF, et al. Genetics, 2020 Feb. PMID 31852725, Free PMC Article
  2. Meiotic errors activate checkpoints that improve gamete quality without triggering apoptosis in male germ cells. Jaramillo-Lambert A, et al. Curr Biol, 2010 Dec 7. PMID 20970339, Free PMC Article
  3. RAD-6: pyrimidine synthesis and radiation sensitivity in Caenorhabditis elegans. Merry A, et al. Biochem J, 2014 Mar 1. PMID 24262006
  4. chk-1 is an essential gene and is required for an S-M checkpoint during early embryogenesis. Kalogeropoulos N, et al. Cell Cycle, 2004 Sep. PMID 15326393
  5. A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint. Lee SJ, et al. Development, 2004 Jun. PMID 15115755

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Serine/threonine-protein kinase chk-1
NP_001024234.1
  • Confirmed by transcript evidence
NP_001380036.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    3757153..3759469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392496.1 → NP_001380036.1  Serine/threonine-protein kinase chk-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17375, Q86FM7, Q9N3Z3
    Conserved Domains (1) summary
    cd14069
    Location:22 → 286
    STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1

  2. NM_001029063.4 → NP_001024234.1  Serine/threonine-protein kinase chk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024234.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N3Z3
    Conserved Domains (2) summary
    smart00220
    Location:4 → 193
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1 → 194
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N3Z3.2

Gene LinkOut

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