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so - sine oculis

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding activity; and transcription coregulator binding activity. Involved in several processes, including eye morphogenesis; insect visual primordium formation; and ring gland development. Located in nucleus. Is expressed in several structures, including embryonic neuroblast; epithelium; imaginal disc; photoreceptor; and photoreceptor neurons. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 23; branchiootorenal syndrome; nephroblastoma; and renal Wilms' tumor. Orthologous to several human genes including SIX1 (SIX homeobox 1). [provided by Alliance of Genome Resources, Oct 2024]

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Species Gene Architecture aa