eve even skipped [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eveprovided by FlyBase
Official Full Name: even skippedprovided by FlyBase
Primary source: FLYBASE:FBgn0000606
Locus tag: Dmel_CG2328
See related: AllianceGenome:FB:FBgn0000606
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 10.5; 10.9; 14.10; 20.35; CG2328; dm-eve; Dm-eve; Dmel\CG2328; E(eve); Eve; EVE; eve2; even; Even; F; l(2)46Ce; l(2)46CFg; l(2)46CFh; l(2)46CFj; l(2)46CFp; l(2)46Cg; V; VI
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including gastrulation involving germ band extension; heart development; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including extended germ band embryo; hindgut; larval internal muscle cell; nervous system; and parasegment. Orthologous to several human genes including EVX2 (even-skipped homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 46C10-46C10; 2-61 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9979319..9980795)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5866824..5868300)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multifaceted effects on even-skipped transcriptional dynamics upon Kruppel dosage changes.
Title: Multifaceted effects on even-skipped transcriptional dynamics upon Krüppel dosage changes.
Functional analysis of the Drosophila eve locus in response to non-canonical combinations of gap gene expression levels.
Title: Functional analysis of the Drosophila eve locus in response to non-canonical combinations of gap gene expression levels.
An insulator blocks access to enhancers by an illegitimate promoter, preventing repression by transcriptional interference.
Title: An insulator blocks access to enhancers by an illegitimate promoter, preventing repression by transcriptional interference.
A novel temporal identity window generates alternating Eve(+)/Nkx6(+) motor neuron subtypes in a single progenitor lineage.
Title: A novel temporal identity window generates alternating Eve(+)/Nkx6(+) motor neuron subtypes in a single progenitor lineage.
Kinetic sculpting of the seven stripes of the Drosophila even-skipped gene.
Title: Kinetic sculpting of the seven stripes of the Drosophila even-skipped gene.
While Hunchback directly represses the eve stripe 3+7 enhancer, study found that in the eve stripe 2+7 enhancer, Hunchback repression is prevented by nearby sequences-this phenomenon is called counter-repression.
Title: Hunchback is counter-repressed to regulate even-skipped stripe 2 expression in Drosophila embryos.
Pericardial cells that express the transcription factor Even Skipped adopt distinct fates along the anterior-posterior axis. Among them, the most anterior Antp-Ubx-AbdA-negative cells form a novel cardiac outflow component we call the outflow hanging structure, whereas the Antp-expressing cells differentiate into wing heart precursors.
Title: Distinct subsets of Eve-positive pericardial cells stabilise cardiac outflow and contribute to Hox gene-triggered heart morphogenesis in Drosophila.
natural variation in a conserved trait-even-skipped (eve) expression at the cellular blastoderm stage of embryonic development in Drosophila melanogaster, was investigated.
Title: Natural variation of the expression pattern of the segmentation gene even-skipped in melanogaster.
Ubiquitous TER94 expression is "replaced" by expression in an eve pattern when Homie is deleted, and this effect is reversed when the PRE is also removed
Title: The Drosophila eve insulator Homie promotes eve expression and protects the adjacent gene from repression by polycomb spreading.
Deletion of any individual enhancer reduced Yan occupancy at the other elements, impacting eve expression, cell fate specification, and cardiac function
Title: 3D chromatin interactions organize Yan chromatin occupancy and repression at the even-skipped locus.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adult heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blastoderm segmentation	TAS Traceable Author Statement more info	PubMed
involved_in cephalic furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-band extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardioblast cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in periodic partitioning by pair rule gene	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEP Inferred from Expression Pattern more info	PubMed
involved_in posterior head segmentation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in trunk segmentation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: even skipped

Names: CG2328-PA; complementation group F; eve PRE/TRE element; eve-PA; even-skiped; even-skipped; evenskip; evenskipped; group V; group VI; lethal(2)46Ce