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Jmjd8 jumonji domain containing 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360498, updated on 2-Nov-2024

Summary

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Official Symbol
Jmjd8provided by RGD
Official Full Name
jumonji domain containing 8provided by RGD
Primary source
RGD:1307381
See related
EnsemblRapid:ENSRNOG00000019729 AllianceGenome:RGD:1307381
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307381
Summary
Predicted to be involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; positive regulation of sprouting angiogenesis; and regulation of pyruvate kinase activity. Predicted to be located in endoplasmic reticulum lumen and nucleus. Predicted to be active in cytoplasm. Orthologous to human JMJD8 (jumonji domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 303.0), Kidney (RPKM 279.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Jmjd8 in Genome Data Viewer
Location:
10q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15353460..15356392)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14848965..14851881)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15195954..15198870)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 16 Neighboring gene WD repeat domain 24 Neighboring gene STIP1 homology and U-box containing protein 1 Neighboring gene rhomboid like 1 Neighboring gene ras homolog family member T2 Neighboring gene WD repeat domain 90

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. JMJD8 is a novel endoplasmic reticulum protein with a JmjC domain. Yeo KS, et al. Sci Rep, 2017 Nov 13. PMID 29133832, Free PMC Article
  2. JMJD8 is a positive regulator of TNF-induced NF-κB signaling. Yeo KS, et al. Sci Rep, 2016 Sep 27. PMID 27671354, Free PMC Article
  3. JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells. Boeckel JN, et al. Arterioscler Thromb Vasc Biol, 2016 Jul. PMID 27199445
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of pyruvate kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of pyruvate kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of pyruvate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
jmjC domain-containing protein 8
Names
jumonji domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014116.1 → NP_001014138.1  jmjC domain-containing protein 8 precursor

    See identical proteins and their annotated locations for NP_001014138.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079205
    UniProtKB/Swiss-Prot
    Q6AY40
    Related
    ENSRNOP00000026789.6, ENSRNOT00000026789.7
    Conserved Domains (1) summary
    cl21464
    Location:61 → 255
    cupin_like; Conserved domain found in cupin and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15353460..15356392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245999.5 → XP_006246061.1  jmjC domain-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QF73, A6HD59
    Conserved Domains (1) summary
    cl21464
    Location:82 → 274
    cupin_like; Conserved domain found in cupin and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY40.4 GenPept UniProtKB/Swiss-Prot:Q6AY40

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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