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Nprl3 NPR3-like, GATOR1 complex subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 360505, updated on 2-Nov-2024

Summary

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Official Symbol
Nprl3provided by RGD
Official Full Name
NPR3-like, GATOR1 complex subunitprovided by RGD
Primary source
RGD:1308665
See related
EnsemblRapid:ENSRNOG00000020541 AllianceGenome:RGD:1308665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mare; RGD1308665
Summary
Predicted to be involved in several processes, including TORC1 signaling; cellular response to amino acid starvation; and negative regulation of TORC1 signaling. Predicted to act upstream of or within circulatory system development and roof of mouth development. Predicted to be part of GATOR1 complex. Predicted to be active in lysosomal membrane. Human ortholog(s) of this gene implicated in familial focal epilepsy with variable foci 3. Orthologous to human NPRL3 (NPR3 like, GATOR1 complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 41.1), Spleen (RPKM 32.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nprl3 in Genome Data Viewer
Location:
10q12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15859739..15900261)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15355361..15395812)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15620824..15661332)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693292 Neighboring gene hemoglobin subunit zeta Neighboring gene N-methylpurine-DNA glycosylase Neighboring gene rhomboid 5 homolog 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nprl3 is required for normal development of the cardiovascular system. Kowalczyk MS, et al. Mamm Genome, 2012 Aug. PMID 22538705
  2. Regulation of mTORC1 by amino acids. Bar-Peled L, et al. Trends Cell Biol, 2014 Jul. PMID 24698685, Free PMC Article
  3. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Bar-Peled L, et al. Science, 2013 May 31. PMID 23723238, Free PMC Article
  4. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Wolfson RL, et al. Nature, 2017 Mar 16. PMID 28199306, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124858

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within roof of mouth development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ventricular septum development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of GATOR1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GATOR1 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GATOR1 complex protein NPRL3
Names
GATOR complex protein NPRL3
nitrogen permease regulator 3-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394235.1 → NP_001381164.1  GATOR1 complex protein NPRL3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2K0K3
    Related
    ENSRNOP00000096488.2, ENSRNOT00000094811.2
    Conserved Domains (1) summary
    cl24021
    Location:76 → 429
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3

  2. NM_001394236.1 → NP_001381165.1  GATOR1 complex protein NPRL3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HDB0
    Related
    ENSRNOP00000071482.2, ENSRNOT00000089435.3
    Conserved Domains (1) summary
    cl24021
    Location:64 → 416
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3

RNA

  1. NR_172092.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    Related
    ENSRNOT00000066430.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15859739..15900261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269323.1 → XP_063125393.1  GATOR1 complex protein NPRL3 isoform X4

  2. XM_006246016.5 → XP_006246078.1  GATOR1 complex protein NPRL3 isoform X5

    UniProtKB/TrEMBL
    Q499Q8
    Conserved Domains (1) summary
    cl24021
    Location:76 → 396
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3

  3. XM_006246011.4 → XP_006246073.1  GATOR1 complex protein NPRL3 isoform X1

    Conserved Domains (1) summary
    cl24021
    Location:38 → 391
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3

  4. XM_039086292.2 → XP_038942220.1  GATOR1 complex protein NPRL3 isoform X2

    Conserved Domains (1) summary
    cl24021
    Location:26 → 378
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3

  5. XM_063269324.1 → XP_063125394.1  GATOR1 complex protein NPRL3 isoform X6

  6. XM_063269325.1 → XP_063125395.1  GATOR1 complex protein NPRL3 isoform X7

  7. XM_006246012.5 → XP_006246074.1  GATOR1 complex protein NPRL3 isoform X3

    Conserved Domains (1) summary
    cl24021
    Location:106 → 375
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3

  8. XM_039086294.2 → XP_038942222.1  GATOR1 complex protein NPRL3 isoform X8

    Conserved Domains (1) summary
    cl24021
    Location:13 → 218
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3

RNA

  1. XR_010055203.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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