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Tbc1d9b TBC1 domain family member 9B [ Rattus norvegicus (Norway rat) ]

Gene ID: 360520, updated on 10-Jul-2024

Summary

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Official Symbol
Tbc1d9bprovided by RGD
Official Full Name
TBC1 domain family member 9Bprovided by RGD
Primary source
RGD:1310147
See related
EnsemblRapid:ENSRNOG00000003050 AllianceGenome:RGD:1310147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310147
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Orthologous to human TBC1D9B (TBC1 domain family member 9B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 139.8), Heart (RPKM 132.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tbc1d9b in Genome Data Viewer
Location:
10q22
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (34961012..34998227)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34459930..34497146)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35637103..35677335)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene RasGEF domain family, member 1C Neighboring gene ring finger protein 130 Neighboring gene microRNA 340-1 Neighboring gene uncharacterized LOC120095090 Neighboring gene MRN complex interacting protein Neighboring gene sequestosome 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional dissection of Rab GTPases involved in primary cilium formation. Yoshimura S, et al. J Cell Biol, 2007 Jul 30. PMID 17646400, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TBC1 domain family member 9B
Names
BUB2-like protein 1
TBC1 domain family, member 9B (with GRAM domain)
vascular Rab-GAP/TBC-containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394243.1 → NP_001381172.1  TBC1 domain family member 9B isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZMR5, F1LRL4
    Related
    ENSRNOP00000047447.5, ENSRNOT00000043085.6
    Conserved Domains (4) summary
    smart00054
    Location:887 → 912
    EFh; EF-hand, calcium binding motif
    smart00164
    Location:506 → 716
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd13354
    Location:299 → 394
    PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
    cd13351
    Location:153 → 251
    PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1

  2. NM_001394244.1 → NP_001381173.1  TBC1 domain family member 9B isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZMR5
    Related
    ENSRNOP00000097642.2, ENSRNOT00000114596.2
    Conserved Domains (4) summary
    smart00054
    Location:887 → 912
    EFh; EF-hand, calcium binding motif
    smart00164
    Location:506 → 716
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd13354
    Location:299 → 394
    PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
    cd13351
    Location:153 → 251
    PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    34961012..34998227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767690.4 → XP_008765912.1  TBC1 domain family member 9B isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZMR5
    Conserved Domains (5) summary
    smart00054
    Location:852 → 877
    EFh; EF-hand, calcium binding motif
    smart00164
    Location:471 → 681
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd13354
    Location:299 → 394
    PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
    cd13351
    Location:153 → 251
    PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1
    cl08302
    Location:821 → 872
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_063269329.1 → XP_063125399.1  TBC1 domain family member 9B isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZMR5

  3. XM_063269328.1 → XP_063125398.1  TBC1 domain family member 9B isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZMR5, A6HDZ6

  4. XM_006246295.5 → XP_006246357.1  TBC1 domain family member 9B isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZMR5, A0A8I6AWL8
    Conserved Domains (5) summary
    smart00054
    Location:887 → 912
    EFh; EF-hand, calcium binding motif
    smart00164
    Location:506 → 716
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd13354
    Location:299 → 394
    PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
    cd13351
    Location:153 → 251
    PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1
    cl08302
    Location:856 → 907
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  5. XM_063269330.1 → XP_063125400.1  TBC1 domain family member 9B isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZMR5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108274.1: Suppressed sequence

    Description
    NM_001108274.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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