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Ncbp3 nuclear cap binding subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360563, updated on 2-Nov-2024

Summary

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Official Symbol
Ncbp3provided by RGD
Official Full Name
nuclear cap binding subunit 3provided by RGD
Primary source
RGD:1308139
See related
EnsemblRapid:ENSRNOG00000018550 AllianceGenome:RGD:1308139
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308139
Summary
Predicted to enable RNA 7-methylguanosine cap binding activity and mRNA binding activity. Predicted to be involved in defense response to virus; mRNA export from nucleus; and snRNA export from nucleus. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of nuclear cap binding activity complex. Predicted to be active in nucleus. Orthologous to human NCBP3 (nuclear cap binding subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 161.3), Adrenal (RPKM 146.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ncbp3 in Genome Data Viewer
Location:
10q24
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (58164241..58193952)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57665716..57695432)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59613398..59643111)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X 1 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1 Neighboring gene integrin subunit alpha E Neighboring gene histone H3 associated protein kinase Neighboring gene coiled-coil-helix-coiled-coil-helix domain-containing protein 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. Gebhardt A, et al. Nat Commun, 2015 Sep 18. PMID 26382858, Free PMC Article
  2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA cap binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA cap binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in snRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear cap binding complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear cap-binding protein subunit 3
Names
uncharacterized protein C17orf85 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108281.1 → NP_001101751.1  nuclear cap-binding protein subunit 3

    See identical proteins and their annotated locations for NP_001101751.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HGH8, D3ZXL5
    Related
    ENSRNOP00000025554.4, ENSRNOT00000025553.6
    Conserved Domains (1) summary
    pfam10309
    Location:123 → 177
    DUF2414; Protein of unknown function (DUF2414)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    58164241..58193952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086326.2 → XP_038942254.1  nuclear cap-binding protein subunit 3 isoform X1

    Conserved Domains (1) summary
    pfam10309
    Location:9 → 63
    NCBP3; Nuclear cap-binding protein subunit 3
Nucleotide Protein Strain
Heading Accession and Version

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