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Ankrd13b ankyrin repeat domain 13B [ Rattus norvegicus (Norway rat) ]

Gene ID: 360575, updated on 10-Jul-2024

Summary

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Official Symbol
Ankrd13bprovided by RGD
Official Full Name
ankyrin repeat domain 13Bprovided by RGD
Primary source
RGD:1564005
See related
EnsemblRapid:ENSRNOG00000014742 AllianceGenome:RGD:1564005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564005
Summary
Predicted to enable ubiquitin-dependent protein binding activity. Predicted to be involved in negative regulation of receptor internalization. Predicted to be located in endosome; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ANKRD13B (ankyrin repeat domain 13B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 45.3), Lung (RPKM 25.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ankrd13b in Genome Data Viewer
Location:
10q24
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (62817791..62836456, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (62319660..62338342, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (62674416..62691949)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene slingshot protein phosphatase 2 Neighboring gene uncharacterized LOC134480826 Neighboring gene uncharacterized LOC120095265 Neighboring gene coronin 6 Neighboring gene GIT ArfGAP 1 Neighboring gene tumor protein p53 inducible protein 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. Tanno H, et al. Mol Biol Cell, 2012 Apr. PMID 22298428, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-modified protein reader activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 13B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430227.1 → NP_001417156.1  ankyrin repeat domain-containing protein 13B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D4A6I3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    62817791..62836456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768134.4 → XP_008766356.1  ankyrin repeat domain-containing protein 13B isoform X2

    See identical proteins and their annotated locations for XP_008766356.1

    UniProtKB/TrEMBL
    D4A1M1
    Conserved Domains (4) summary
    cd00204
    Location:13 → 105
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam11904
    Location:163 → 490
    GPCR_chapero_1; GPCR-chaperone
    pfam13857
    Location:34 → 88
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]

  2. XM_008768135.4 → XP_008766357.1  ankyrin repeat domain-containing protein 13B isoform X1

    See identical proteins and their annotated locations for XP_008766357.1

    UniProtKB/TrEMBL
    D4A1M1
    Related
    ENSRNOP00000052960.3, ENSRNOT00000056110.5
    Conserved Domains (4) summary
    cd00204
    Location:13 → 105
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam11904
    Location:163 → 490
    GPCR_chapero_1; GPCR-chaperone
    pfam13857
    Location:34 → 88
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]

  3. XM_008768137.4 → XP_008766359.1  ankyrin repeat domain-containing protein 13B isoform X3

    Related
    ENSRNOP00000111276.1, ENSRNOT00000145817.1
    Conserved Domains (4) summary
    cd00204
    Location:13 → 105
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam11904
    Location:163 → 490
    GPCR_chapero_1; GPCR-chaperone
    pfam13857
    Location:34 → 88
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]

  4. XM_008768138.4 → XP_008766360.1  ankyrin repeat domain-containing protein 13B isoform X3

    See identical proteins and their annotated locations for XP_008766360.1

    UniProtKB/TrEMBL
    D4A6I3
    Conserved Domains (4) summary
    cd00204
    Location:13 → 105
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam11904
    Location:163 → 490
    GPCR_chapero_1; GPCR-chaperone
    pfam13857
    Location:34 → 88
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]

  5. XM_017597656.3 → XP_017453145.1  ankyrin repeat domain-containing protein 13B isoform X3

    UniProtKB/TrEMBL
    D4A6I3
    Conserved Domains (4) summary
    cd00204
    Location:13 → 105
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam11904
    Location:163 → 490
    GPCR_chapero_1; GPCR-chaperone
    pfam13857
    Location:34 → 88
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:13 → 45
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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