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Nfe2l1 NFE2 like bZIP transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360610, updated on 17-Aug-2024

Summary

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Official Symbol
Nfe2l1provided by RGD
Official Full Name
NFE2 like bZIP transcription factor 1provided by RGD
Primary source
RGD:1311972
See related
EnsemblRapid:ENSRNOG00000008830 AllianceGenome:RGD:1311972
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases for genes in the "nuclear respiratory factor" and "nuclear factor (erythroid-derived 2)" families due to a shared symbol or alias pattern of NRF*. [provided by RefSeq, Jul 2008]
Expression
Biased expression in Muscle (RPKM 712.1), Heart (RPKM 704.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nfe2l1 in Genome Data Viewer
Location:
10q31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82296824..82309472, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (81796055..81812926, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84686762..84699313, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480860 Neighboring gene chromobox 1 Neighboring gene uncharacterized LOC120095287 Neighboring gene microRNA 152 Neighboring gene COPI coat complex subunit zeta 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways. Baird L, et al. Mol Cell Biol, 2017 Feb 15. PMID 27920251, Free PMC Article
  2. Icariin induces synoviolin expression through NFE2L1 to protect neurons from ER stress-induced apoptosis. Li F, et al. PLoS One, 2015. PMID 25806530, Free PMC Article
  3. The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression. Zhang Y, et al. PLoS One, 2014. PMID 25290918, Free PMC Article
  4. Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice. Lee CS, et al. FEBS J, 2013 Aug. PMID 23702335, Free PMC Article
  5. The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts. Kwong M, et al. J Biol Chem, 1999 Dec 24. PMID 10601325

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our study reveals Icariin-induced Synoviolin expression through NFE2L1 as a previously unappreciated molecular mechanism underlying the neuronal protective function of Icariin.
    Title: Icariin induces synoviolin expression through NFE2L1 to protect neurons from ER stress-induced apoptosis.
  2. Nrf1 regulates rat glutamate-cysteine ligase catalytic subunit promoter by modulating the expression of key AP-1 and NF-kappaB family members.
    Title: Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1.
  3. the physical interaction between Nrf1 and C/EBPbeta provide a novel mechanism for the transcriptional regulation of DSPP in odontoblasts.
    Title: The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to cold ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to copper ion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cysteine transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fructose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glial cell fate commitment ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glucose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of nucleus organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of odontoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spinal cord motor neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endoplasmic reticulum membrane sensor NFE2L1
Names
nuclear factor erythroid 2-related factor 1
nuclear factor, erythroid 2-like 1
nuclear factor, erythroid derived 2,-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108293.2 → NP_001101763.2  endoplasmic reticulum membrane sensor NFE2L1 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    CK839329, JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6A8A5, A6HIG7, D4A349
    Related
    ENSRNOP00000061935.4, ENSRNOT00000067542.5
    Conserved Domains (1) summary
    cd14720
    Location:618 → 685
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

  2. NM_001372250.1 → NP_001359179.1  endoplasmic reticulum membrane sensor NFE2L1 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    CK839329, JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6A8A5, A6HIG7, D4A349
    Related
    ENSRNOP00000087333.2, ENSRNOT00000103907.2
    Conserved Domains (1) summary
    cd14720
    Location:618 → 685
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

  3. NM_001372251.1 → NP_001359180.1  endoplasmic reticulum membrane sensor NFE2L1 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a distinct ATG, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    CK839329, JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6A9I5
    Related
    ENSRNOP00000088301.1, ENSRNOT00000111539.2
    Conserved Domains (1) summary
    cd14720
    Location:460 → 527
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    82296824..82309472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247238.5 → XP_006247300.1  endoplasmic reticulum membrane sensor NFE2L1 isoform X1

    See identical proteins and their annotated locations for XP_006247300.1

    Conserved Domains (1) summary
    cd14720
    Location:491 → 558
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version

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