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Scrn2 secernin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360612, updated on 5-Mar-2024

Summary

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Official Symbol
Scrn2provided by RGD
Official Full Name
secernin 2provided by RGD
Primary source
RGD:1307741
See related
Ensembl:ENSRNOG00000010214 AllianceGenome:RGD:1307741
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in proteolysis. Orthologous to human SCRN2 (secernin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 53.1), Liver (RPKM 50.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Scrn2 in Genome Data Viewer
Location:
10q31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82513043..82517115)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82016604..82020676)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84966862..84971022)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352124 Neighboring gene Sp6 transcription factor Neighboring gene leucine rich repeat containing 46 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene oxysterol binding protein-like 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type exopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
secernin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012142.1 → NP_001012142.1  secernin-2

    See identical proteins and their annotated locations for NP_001012142.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078939
    UniProtKB/Swiss-Prot
    Q6AYR8
    UniProtKB/TrEMBL
    A6HII4
    Conserved Domains (1) summary
    cl00467
    Location:11 → 399
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    82513043..82517115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597394.2 → XP_017452883.1  secernin-2 isoform X2

    UniProtKB/TrEMBL
    A6HII4
    Conserved Domains (1) summary
    cl00467
    Location:48 → 372
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

  2. XM_039086390.2 → XP_038942318.1  secernin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYR8
    UniProtKB/TrEMBL
    A6HII4
    Related
    ENSRNOP00000013580.4
    Conserved Domains (1) summary
    cl00467
    Location:11 → 399
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

  3. XM_006247342.5 → XP_006247404.1  secernin-2 isoform X1

    See identical proteins and their annotated locations for XP_006247404.1

    UniProtKB/Swiss-Prot
    Q6AYR8
    UniProtKB/TrEMBL
    A6HII4
    Conserved Domains (1) summary
    cl00467
    Location:11 → 399
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

  4. XM_039086392.2 → XP_038942320.1  secernin-2 isoform X3

    Conserved Domains (1) summary
    cl00467
    Location:11 → 184
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

  5. XM_039086391.2 → XP_038942319.1  secernin-2 isoform X2

    UniProtKB/TrEMBL
    A6HII4
    Conserved Domains (1) summary
    cl00467
    Location:48 → 372
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYR8.1 GenPept UniProtKB/Swiss-Prot:Q6AYR8

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