Krt19 keratin 19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Krt19provided by RGD
Official Full Name: keratin 19provided by RGD
Primary source: RGD:619936
See related: EnsemblRapid:ENSRNOG00000071326 AllianceGenome:RGD:619936
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ka19; Krt1-19
Summary: Predicted to be a structural constituent of muscle. Predicted to be involved in cytoskeleton organization; epithelial cell differentiation; and response to estrogen. Predicted to act upstream of or within Notch signaling pathway and cell differentiation involved in embryonic placenta development. Part of dystrophin-associated glycoprotein complex. Orthologous to human KRT19 (keratin 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 727.1), Uterus (RPKM 188.2) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (85576235..85580952, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (85075835..85080552, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88055843..88060560, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cytokeratins 8 and 19 are expressed in adult striated muscle, where they may contribute to the organization of both the myoplasm and sarcolemma
Title: Cloning and characterization of cytokeratins 8 and 19 in adult rat striated muscle. Interaction with the dystrophin glycoprotein complex.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137070 (e-PCR)
- UniSTS:219158

D10Wox56 (e-PCR)
- UniSTS:518596

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation involved in embryonic placenta development	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in costamere	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
part_of dystrophin-associated glycoprotein complex	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in terminal web	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: keratin, type I cytoskeletal 19

Names: CK-19; K19; cytokeratin 19; keratin 19, type I; keratin complex 1, acidic, gene 19; type I keratin KA19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.