U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fkbp10 FKBP prolyl isomerase 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360627, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Fkbp10provided by RGD
Official Full Name
FKBP prolyl isomerase 10provided by RGD
Primary source
RGD:1549751
See related
EnsemblRapid:ENSRNOG00000015941 AllianceGenome:RGD:1549751
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable FK506 binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to act upstream of or within several processes, including aorta morphogenesis; extracellular matrix organization; and peptidyl-lysine hydroxylation. Predicted to be located in membrane and mitochondrial intermembrane space. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 11. Orthologous to human FKBP10 (FKBP prolyl isomerase 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Uterus (RPKM 139.6), Adrenal (RPKM 117.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Fkbp10 in Genome Data Viewer
Location:
10q31
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (85845801..85858361)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85345434..85357998)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88326337..88338199)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095292 Neighboring gene junction plakoglobin Neighboring gene uncharacterized LOC134480874 Neighboring gene prolyl 3-hydroxylase family member 4 Neighboring gene 5'-nucleotidase, cytosolic IIIB Neighboring gene kelch-like family member 10

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65). Coss MC, et al. J Biol Chem, 1995 Dec 8. PMID 7493967
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FK506 binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within collagen fibril organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-lysine hydroxylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-proline modification ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP10
Names
FK506 binding protein 10
NP_001014142.1
XP_038942330.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014120.1 → NP_001014142.1  peptidyl-prolyl cis-trans isomerase FKBP10 precursor

    See identical proteins and their annotated locations for NP_001014142.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085854
    UniProtKB/TrEMBL
    A0A096MJW1, F7EYM3, Q5U2V1
    Related
    ENSRNOP00000068283.2, ENSRNOT00000076475.4
    Conserved Domains (2) summary
    cd00051
    Location:505 → 566
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00254
    Location:54 → 146
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    85845801..85858361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086402.2 → XP_038942330.1  peptidyl-prolyl cis-trans isomerase FKBP10 isoform X1

    UniProtKB/TrEMBL
    A0A096MJW1
    Conserved Domains (2) summary
    cd00051
    Location:544 → 605
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00254
    Location:54 → 146
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools