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Slc25a39 solute carrier family 25, member 39 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360636, updated on 2-Nov-2024

Summary

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Official Symbol
Slc25a39provided by RGD
Official Full Name
solute carrier family 25, member 39provided by RGD
Primary source
RGD:1306193
See related
EnsemblRapid:ENSRNOG00000020994 AllianceGenome:RGD:1306193
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306193
Summary
Predicted to enable 2 iron, 2 sulfur cluster binding activity and glutathione transmembrane transporter activity. Predicted to be involved in cellular response to iron ion and glutathione import into mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human SLC25A39 (solute carrier family 25 member 39). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 597.3), Testes (RPKM 484.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc25a39 in Genome Data Viewer
Location:
10q32.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (87862630..87867626, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87362494..87367358, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90351899..90356905, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene partner of NOB1 homolog (S. cerevisiae), pseudogene 1 Neighboring gene RUN domain containing 3A Neighboring gene granulin precursor Neighboring gene family with sequence similarity 171, member A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 2 iron, 2 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables 2 iron, 2 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glutathione transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to iron ion IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to iron ion ISO
Inferred from Sequence Orthology
more info
  
involved_in glutathione import into mitochondrion IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione import into mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in glutathione import into mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial glutathione transporter SLC25A39; probable mitochondrial glutathione transporter SLC25A39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024792.1 → NP_001019963.1  mitochondrial glutathione transporter SLC25A39

    See identical proteins and their annotated locations for NP_001019963.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097349
    UniProtKB/Swiss-Prot
    Q4V8K4
    UniProtKB/TrEMBL
    A0A8L2QFK6, A6HJJ4
    Related
    ENSRNOP00000028496.6, ENSRNOT00000028496.6
    Conserved Domains (2) summary
    pfam00153
    Location:254 → 350
    Mito_carr; Mitochondrial carrier protein
    pfam18398
    Location:71 → 94
    CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    87862630..87867626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247374.5 → XP_006247436.1  probable mitochondrial glutathione transporter SLC25A39 isoform X1

    See identical proteins and their annotated locations for XP_006247436.1

    UniProtKB/Swiss-Prot
    Q4V8K4
    UniProtKB/TrEMBL
    A0A8L2QFK6, A6HJJ4
    Conserved Domains (2) summary
    pfam00153
    Location:254 → 350
    Mito_carr; Mitochondrial carrier protein
    pfam18398
    Location:71 → 94
    CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

  2. XM_006247376.4 → XP_006247438.1  probable mitochondrial glutathione transporter SLC25A39 isoform X1

    See identical proteins and their annotated locations for XP_006247438.1

    UniProtKB/Swiss-Prot
    Q4V8K4
    UniProtKB/TrEMBL
    A0A8L2QFK6, A6HJJ4
    Conserved Domains (2) summary
    pfam00153
    Location:254 → 350
    Mito_carr; Mitochondrial carrier protein
    pfam18398
    Location:71 → 94
    CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

  3. XM_039086411.2 → XP_038942339.1  probable mitochondrial glutathione transporter SLC25A39 isoform X1

    UniProtKB/Swiss-Prot
    Q4V8K4
    UniProtKB/TrEMBL
    A0A8L2QFK6, A6HJJ4
    Conserved Domains (2) summary
    pfam00153
    Location:254 → 350
    Mito_carr; Mitochondrial carrier protein
    pfam18398
    Location:71 → 94
    CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

  4. XM_039086412.1 → XP_038942340.1  probable mitochondrial glutathione transporter SLC25A39 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:153 → 249
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8K4.1 GenPept UniProtKB/Swiss-Prot:Q4V8K4

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