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Map3k14 mitogen-activated protein kinase kinase kinase 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360640, updated on 10-Jul-2024

Summary

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Official Symbol
Map3k14provided by RGD
Official Full Name
mitogen-activated protein kinase kinase kinase 14provided by RGD
Primary source
RGD:1310487
See related
EnsemblRapid:ENSRNOG00000003278 AllianceGenome:RGD:1310487
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein kinase activity. Involved in protein phosphorylation. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Orthologous to human MAP3K14 (mitogen-activated protein kinase kinase kinase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 57.3), Thymus (RPKM 50.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Map3k14 in Genome Data Viewer
Location:
10q32.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88665417..88715669, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (88165349..88215558, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91303428..91353601, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene formin-like 1 Neighboring gene EF-hand calcium binding domain 15 Neighboring gene uncharacterized LOC120095296 Neighboring gene spermatogenesis associated 32 Neighboring gene uncharacterized LOC120095297 Neighboring gene Rho GTPase activating protein 27 Neighboring gene uncharacterized LOC134480883 Neighboring gene pleckstrin homology and RUN domain containing M1 Neighboring gene uncharacterized LOC134480884

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protective effect of Ginkgolids (A+B) is associated with inhibition of NIK/IKK/IkappaB/NF-kappaB signaling pathway in a rat model of permanent focal cerebral ischemia. Wang X, et al. Brain Res, 2008 Oct 9. PMID 18722355
  2. Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells. Saitoh Y, et al. Blood, 2008 May 15. PMID 18305221
  3. NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1. Lee EJ, et al. J Biol Chem, 2008 Feb 8. PMID 18056702
  4. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Xiao G, et al. Mol Cell, 2001 Feb. PMID 11239468
  5. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Ling L, et al. Proc Natl Acad Sci U S A, 1998 Mar 31. PMID 9520446, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. deregulated expression of NIK plays a critical role in constitutive NF-kappaB activation in ATL and H-RS cells
    Title: Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.
  2. NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1
    Title: NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 14
NP_001101771.1
XP_038942345.1
XP_038942346.1
XP_038942347.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108301.1 → NP_001101771.1  mitogen-activated protein kinase kinase kinase 14

    See identical proteins and their annotated locations for NP_001101771.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HJQ8, A6HJQ9, D3ZTD1
    Related
    ENSRNOP00000004532.5, ENSRNOT00000004532.7
    Conserved Domains (2) summary
    smart00220
    Location:408 → 667
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13991
    Location:395 → 662
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    88665417..88715669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086417.2 → XP_038942345.1  mitogen-activated protein kinase kinase kinase 14 isoform X1

    Conserved Domains (1) summary
    cd13991
    Location:133 → 400
    STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

  2. XM_039086419.2 → XP_038942347.1  mitogen-activated protein kinase kinase kinase 14 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 192
    PKc_like; Protein Kinases, catalytic domain

  3. XM_039086418.2 → XP_038942346.1  mitogen-activated protein kinase kinase kinase 14 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:395 → 432
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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