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Icam2 intercellular adhesion molecule 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360647, updated on 17-Aug-2024

Summary

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Official Symbol
Icam2provided by RGD
Official Full Name
intercellular adhesion molecule 2provided by RGD
Primary source
RGD:1359660
See related
EnsemblRapid:ENSRNOG00000025143 AllianceGenome:RGD:1359660
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion. Predicted to be located in cleavage furrow; microvillus; and uropod. Predicted to be integral component of plasma membrane. Orthologous to human ICAM2 (intercellular adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 320.7), Thymus (RPKM 258.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Icam2 in Genome Data Viewer
Location:
10q32.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (91808449..91819319, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91308608..91319536, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94569889..94581218, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene CD79b molecule Neighboring gene sodium voltage-gated channel alpha subunit 4 Neighboring gene uncharacterized LOC108352146 Neighboring gene proline rich 29 Neighboring gene endoplasmic reticulum to nucleus signaling 1 Neighboring gene ribosomal protein S10, pseudogene 6 Neighboring gene uncharacterized LOC102546698 Neighboring gene small nucleolar RNA, C/D box 104

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ICAM-2 and lipid rafts disappear from the basal plasma membrane of uterine epithelial cells during early pregnancy in rats. Lecce L, et al. Cell Tissue Res, 2013 Sep. PMID 23736379
  2. Intercellular adhesion molecule-2 is involved in apical ectoplasmic specialization dynamics during spermatogenesis in the rat. Xiao X, et al. J Endocrinol, 2013 Jan. PMID 23097088, Free PMC Article
  3. Isolation, characterization, and expression of mouse ICAM-2 complementary and genomic DNA. Xu H, et al. J Immunol, 1992 Oct 15. PMID 1401904
  4. Overlapping and selective roles of endothelial intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in lymphocyte trafficking. Lehmann JC, et al. J Immunol, 2003 Sep 1. PMID 12928410
  5. Polar redistribution of the sialoglycoprotein CD43: implications for T cell function. Savage ND, et al. J Immunol, 2002 Apr 15. PMID 11937524

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC95023

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in uropod ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
intercellular adhesion molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007725.1 → NP_001007726.1  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_001007726.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079465
    UniProtKB/TrEMBL
    F7F7V6, Q6AXM6
    Related
    ENSRNOP00000034319.3, ENSRNOT00000035474.5
    Conserved Domains (2) summary
    pfam03921
    Location:24 → 111
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:114 → 205
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    91808449..91819319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269470.1 → XP_063125540.1  intercellular adhesion molecule 2 isoform X3

    UniProtKB/TrEMBL
    A6HK43

  2. XM_006247624.5 → XP_006247686.1  intercellular adhesion molecule 2 isoform X1

    See identical proteins and their annotated locations for XP_006247686.1

    UniProtKB/TrEMBL
    F7F7V6, Q6AXM6
    Conserved Domains (2) summary
    pfam03921
    Location:24 → 111
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:114 → 205
    Ig; Immunoglobulin domain

  3. XM_006247627.5 → XP_006247689.1  intercellular adhesion molecule 2 isoform X1

    See identical proteins and their annotated locations for XP_006247689.1

    UniProtKB/TrEMBL
    F7F7V6, Q6AXM6
    Conserved Domains (2) summary
    pfam03921
    Location:24 → 111
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:114 → 205
    Ig; Immunoglobulin domain

  4. XM_063269464.1 → XP_063125534.1  intercellular adhesion molecule 2 isoform X1

    UniProtKB/TrEMBL
    F7F7V6, Q6AXM6

  5. XM_063269466.1 → XP_063125536.1  intercellular adhesion molecule 2 isoform X1

    UniProtKB/TrEMBL
    F7F7V6, Q6AXM6

  6. XM_008768379.4 → XP_008766601.1  intercellular adhesion molecule 2 isoform X1

    See identical proteins and their annotated locations for XP_008766601.1

    UniProtKB/TrEMBL
    F7F7V6, Q6AXM6
    Conserved Domains (2) summary
    pfam03921
    Location:24 → 111
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:114 → 205
    Ig; Immunoglobulin domain

  7. XM_063269465.1 → XP_063125535.1  intercellular adhesion molecule 2 isoform X1

    UniProtKB/TrEMBL
    F7F7V6, Q6AXM6

  8. XM_063269467.1 → XP_063125537.1  intercellular adhesion molecule 2 isoform X1

    UniProtKB/TrEMBL
    F7F7V6, Q6AXM6

  9. XM_063269463.1 → XP_063125533.1  intercellular adhesion molecule 2 isoform X1

    UniProtKB/TrEMBL
    F7F7V6, Q6AXM6

  10. XM_063269469.1 → XP_063125539.1  intercellular adhesion molecule 2 isoform X1

    UniProtKB/TrEMBL
    F7F7V6, Q6AXM6

  11. XM_063269468.1 → XP_063125538.1  intercellular adhesion molecule 2 isoform X1

    UniProtKB/TrEMBL
    F7F7V6, Q6AXM6

  12. XM_039086420.2 → XP_038942348.1  intercellular adhesion molecule 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZNQ0
    Related
    ENSRNOP00000079806.1, ENSRNOT00000115213.2
    Conserved Domains (3) summary
    cd00096
    Location:113 → 120
    Ig; Ig strand A [structural motif]
    cd20995
    Location:27 → 111
    IgI_N_ICAM-2; N-terminal immunoglobulin domain of the intercellular adhesion molecules ICAM-2 (Cluster of Differentiation 102 or CD102); member of the I-set of IgSF domains
    cl11960
    Location:113 → 210
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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