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Tepsin TEPSIN, adaptor related protein complex 4 accessory protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 360673, updated on 9-Jul-2024

Summary

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Official Symbol
Tepsinprovided by RGD
Official Full Name
TEPSIN, adaptor related protein complex 4 accessory proteinprovided by RGD
Primary source
RGD:1307410
See related
Ensembl:ENSRNOG00000028161 AllianceGenome:RGD:1307410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Enthd2; RGD1307410
Summary
Located in coated vesicle membrane. Orthologous to human TEPSIN (TEPSIN adaptor related protein complex 4 accessory protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 45.5), Spleen (RPKM 35.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tepsin in Genome Data Viewer
Location:
10q32.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (105872363..105879731, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105373939..105381310, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109271161..109278745, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 131 Neighboring gene microRNA 3594 Neighboring gene microRNA 3562 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 8 Neighboring gene solute carrier family 38, member 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular Basis for the Interaction Between AP4 β4 and its Accessory Protein, Tepsin. Frazier MN, et al. Traffic, 2016 Apr. PMID 26756312, Free PMC Article
  2. Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex. Mattera R, et al. J Biol Chem, 2015 Dec 25. PMID 26542808, Free PMC Article
  3. Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles. Borner GH, et al. J Cell Biol, 2012 Apr 2. PMID 22472443, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of AP-4 adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in coated vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in coated vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in extrinsic component of organelle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AP-4 complex accessory subunit tepsin
Names
ENTH domain containing 2
ENTH domain-containing protein 2
tetra-epsin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100729.1 → NP_001094199.1  AP-4 complex accessory subunit tepsin

    See identical proteins and their annotated locations for NP_001094199.1

    Status: VALIDATED

    Source sequence(s)
    BC089956, JAXUCZ010000010
    UniProtKB/Swiss-Prot
    G3V8Y7, Q5EB78
    UniProtKB/TrEMBL
    A0A8L2QJ15
    Related
    ENSRNOP00000079089.1, ENSRNOT00000106724.2
    Conserved Domains (1) summary
    cd03572
    Location:16 → 134
    ENTH_like_Tepsin; Epsin N-Terminal Homology (ENTH)-like domain of AP-4 complex accessory subunit Tepsin and similar domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    105872363..105879731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247895.5 → XP_006247957.1  AP-4 complex accessory subunit tepsin isoform X2

    See identical proteins and their annotated locations for XP_006247957.1

    UniProtKB/TrEMBL
    A0A8L2QJ15
    Conserved Domains (1) summary
    cd03572
    Location:13 → 125
    ENTH_epsin_related; ENTH domain, Epsin Related family; composed of hypothetical proteins containing an ENTH-like domain. The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in ...

  2. XM_006247894.5 → XP_006247956.1  AP-4 complex accessory subunit tepsin isoform X2

    See identical proteins and their annotated locations for XP_006247956.1

    UniProtKB/TrEMBL
    A0A8L2QJ15
    Conserved Domains (1) summary
    cd03572
    Location:13 → 125
    ENTH_epsin_related; ENTH domain, Epsin Related family; composed of hypothetical proteins containing an ENTH-like domain. The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in ...

  3. XM_039086442.2 → XP_038942370.1  AP-4 complex accessory subunit tepsin isoform X1

    UniProtKB/TrEMBL
    A0A8L2QJ15
    Related
    ENSRNOP00000096998.2, ENSRNOT00000099857.2
    Conserved Domains (1) summary
    cd03572
    Location:9 → 126
    ENTH_like_Tepsin; Epsin N-Terminal Homology (ENTH)-like domain of AP-4 complex accessory subunit Tepsin and similar domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3V8Y7.1 GenPept UniProtKB/Swiss-Prot:G3V8Y7

Gene LinkOut

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