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Wdr45b WD repeat domain 45B [ Rattus norvegicus (Norway rat) ]

Gene ID: 360682, updated on 2-Nov-2024

Summary

Official Symbol
Wdr45bprovided by RGD
Official Full Name
WD repeat domain 45Bprovided by RGD
Primary source
RGD:1305141
See related
EnsemblRapid:ENSRNOG00000036662 AllianceGenome:RGD:1305141
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
WIPI-3; Wdr45l; RGD1305141
Summary
Predicted to enable TSC1-TSC2 complex binding activity; phosphatidylinositol-3,5-bisphosphate binding activity; and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagy of mitochondrion; cellular response to starvation; and macroautophagy. Predicted to be located in lysosome and phagophore assembly site. Predicted to be active in cytosol and phagophore assembly site membrane. Orthologous to human WDR45B (WD repeat domain 45B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 125.3), Thymus (RPKM 122.6) and 9 other tissues See more
Orthologs
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Genomic context

See Wdr45b in Genome Data Viewer
Location:
10q32.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (107097655..107127839, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106597558..106629488, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (110523843..110555769, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480920 Neighboring gene forkhead box K2 Neighboring gene Rab40b, member RAS oncogene family Neighboring gene fructosamine-3-kinase-related protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables TSC1-TSC2 complex binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in glycophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein lipidation involved in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in phagophore assembly site ISO
Inferred from Sequence Orthology
more info
 
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
WD repeat domain phosphoinositide-interacting protein 3
Names
D16Bwg0193e
Wdr45 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039587.1NP_001034676.1  WD repeat domain phosphoinositide-interacting protein 3

    See identical proteins and their annotated locations for NP_001034676.1

    Status: PROVISIONAL

    Source sequence(s)
    AM182327
    UniProtKB/TrEMBL
    Q2MCP5
    Related
    ENSRNOP00000051801.2, ENSRNOT00000054918.5
    Conserved Domains (2) summary
    sd00039
    Location:145183
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:25258
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    107097655..107127839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086444.2XP_038942372.1  WD repeat domain phosphoinositide-interacting protein 3 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:106143
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:59181
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_039086445.2XP_038942373.1  WD repeat domain phosphoinositide-interacting protein 3 isoform X2

    Conserved Domains (1) summary
    cl29593
    Location:25205
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...