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Tmem50b transmembrane protein 50B [ Rattus norvegicus (Norway rat) ]

Gene ID: 360698, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem50bprovided by RGD
Official Full Name
transmembrane protein 50Bprovided by RGD
Primary source
RGD:1307561
See related
EnsemblRapid:ENSRNOG00000002028 AllianceGenome:RGD:1307561
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307561
Summary
Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway. Predicted to be located in endoplasmic reticulum. Orthologous to human TMEM50B (transmembrane protein 50B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 297.6), Brain (RPKM 296.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem50b in Genome Data Viewer
Location:
11q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (44290805..44323650, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (30804835..30837675, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (31719441..31752276, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS7-like Neighboring gene uncharacterized LOC134481058 Neighboring gene interferon gamma receptor 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene SON DNA and RNA binding protein Neighboring gene phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transmembrane protein 50b (C21orf4), a candidate for Down syndrome neurophenotypes, encodes an intracellular membrane protein expressed in the rodent brain. Moldrich RX, et al. Neuroscience, 2008 Jul 17. PMID 18541381
  2. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tmem50b is a developmentally-regulated intracellular ER and Golgi apparatus membrane protein that may prove important for correct brain development through functions associated with precursor cells and glia.
    Title: Transmembrane protein 50b (C21orf4), a candidate for Down syndrome neurophenotypes, encodes an intracellular membrane protein expressed in the rodent brain.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC109374

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 50B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025014.1 → NP_001020185.1  transmembrane protein 50B

    See identical proteins and their annotated locations for NP_001020185.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091349
    UniProtKB/TrEMBL
    A6JLG5, A6JLG6, Q5BJS6
    Related
    ENSRNOP00000002775.5, ENSRNOT00000002775.7
    Conserved Domains (1) summary
    pfam05255
    Location:9 → 157
    UPF0220; Uncharacterized protein family (UPF0220)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    44290805..44323650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270610.1 → XP_063126680.1  transmembrane protein 50B isoform X1

    UniProtKB/TrEMBL
    A6JLG5, A6JLG6, Q5BJS6

  2. XM_017598025.3 → XP_017453514.1  transmembrane protein 50B isoform X1

    UniProtKB/TrEMBL
    A6JLG5, A6JLG6, Q5BJS6
    Conserved Domains (1) summary
    pfam05255
    Location:9 → 157
    UPF0220; Uncharacterized protein family (UPF0220)

  3. XM_006248066.5 → XP_006248128.1  transmembrane protein 50B isoform X1

    See identical proteins and their annotated locations for XP_006248128.1

    UniProtKB/TrEMBL
    A6JLG5, A6JLG6, Q5BJS6
    Conserved Domains (1) summary
    pfam05255
    Location:9 → 157
    UPF0220; Uncharacterized protein family (UPF0220)

  4. XM_006248067.5 → XP_006248129.1  transmembrane protein 50B isoform X1

    See identical proteins and their annotated locations for XP_006248129.1

    UniProtKB/TrEMBL
    A6JLG5, A6JLG6, Q5BJS6
    Conserved Domains (1) summary
    pfam05255
    Location:9 → 157
    UPF0220; Uncharacterized protein family (UPF0220)

  5. XM_063270609.1 → XP_063126679.1  transmembrane protein 50B isoform X1

    UniProtKB/TrEMBL
    A6JLG5, A6JLG6, Q5BJS6

  6. XM_006248068.5 → XP_006248130.1  transmembrane protein 50B isoform X1

    See identical proteins and their annotated locations for XP_006248130.1

    UniProtKB/TrEMBL
    A6JLG5, A6JLG6, Q5BJS6
    Conserved Domains (1) summary
    pfam05255
    Location:9 → 157
    UPF0220; Uncharacterized protein family (UPF0220)

  7. XM_039088458.2 → XP_038944386.1  transmembrane protein 50B isoform X1

    UniProtKB/TrEMBL
    A6JLG5, A6JLG6, Q5BJS6
    Conserved Domains (1) summary
    pfam05255
    Location:9 → 157
    UPF0220; Uncharacterized protein family (UPF0220)

  8. XM_063270612.1 → XP_063126682.1  transmembrane protein 50B isoform X1

    UniProtKB/TrEMBL
    A6JLG5, A6JLG6, Q5BJS6

  9. XM_063270611.1 → XP_063126681.1  transmembrane protein 50B isoform X1

    UniProtKB/TrEMBL
    A6JLG5, A6JLG6, Q5BJS6

  10. XM_063270613.1 → XP_063126683.1  transmembrane protein 50B isoform X1

    UniProtKB/TrEMBL
    A6JLG5, A6JLG6, Q5BJS6
Nucleotide Protein Strain
Heading Accession and Version

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