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Ppil2 peptidylprolyl isomerase like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360746, updated on 2-Nov-2024

Summary

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Official Symbol
Ppil2provided by RGD
Official Full Name
peptidylprolyl isomerase like 2provided by RGD
Primary source
RGD:1309484
See related
EnsemblRapid:ENSRNOG00000026900 AllianceGenome:RGD:1309484
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin-ubiquitin ligase activity. Predicted to be involved in protein folding and protein localization to plasma membrane. Predicted to act upstream of or within protein polyubiquitination. Predicted to be located in cytoplasm; nucleoplasm; and plasma membrane. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human PPIL2 (peptidylprolyl isomerase like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 173.2), Adrenal (RPKM 154.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppil2 in Genome Data Viewer
Location:
11q23
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (97401944..97424581)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83897719..83920970)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (88147342..88169968)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2610318N02 gene like Neighboring gene microRNA 301b Neighboring gene microRNA 130b Neighboring gene yippee-like 1 Neighboring gene mitogen activated protein kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60. Pushkarsky T, et al. J Biol Chem, 2005 Jul 29. PMID 15946952
  2. Spliceosomal immunophilins. Mesa A, et al. FEBS Lett, 2008 Jul 9. PMID 18544344, Free PMC Article
  3. U box proteins as a new family of ubiquitin-protein ligases. Hatakeyama S, et al. J Biol Chem, 2001 Aug 31. PMID 11435423
  4. Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. Davis TL, et al. PLoS Biol, 2010 Jul 27. PMID 20676357, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RING-type E3 ubiquitin-protein ligase PPIL2
Names
peptidyl-prolyl cis-trans isomerase-like 2
peptidylprolyl isomerase (cyclophilin)-like 2
NP_001017383.1
XP_063126732.1
XP_063126733.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017383.1 → NP_001017383.1  RING-type E3 ubiquitin-protein ligase PPIL2

    See identical proteins and their annotated locations for NP_001017383.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085890
    UniProtKB/TrEMBL
    A6JSN3, Q5RKH8
    Related
    ENSRNOP00000035467.6, ENSRNOT00000034506.6
    Conserved Domains (2) summary
    smart00504
    Location:42 → 96
    Ubox; Modified RING finger domain
    cd01923
    Location:281 → 440
    cyclophilin_RING; cyclophilin_RING: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    97401944..97424581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270662.1 → XP_063126732.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X1

    UniProtKB/TrEMBL
    F7FHL6

  2. XM_063270663.1 → XP_063126733.1  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X2

RNA

  1. XR_010055963.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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