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Lnx2 ligand of numb-protein X 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360761, updated on 2-Nov-2024

Summary

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Official Symbol
Lnx2provided by RGD
Official Full Name
ligand of numb-protein X 2provided by RGD
Primary source
RGD:1308222
See related
EnsemblRapid:ENSRNOG00000000955 AllianceGenome:RGD:1308222
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable PDZ domain binding activity; identical protein binding activity; and ubiquitin-protein transferase activity. Predicted to act upstream of or within neural precursor cell proliferation and neuron differentiation. Predicted to be located in plasma membrane. Orthologous to human LNX2 (ligand of numb-protein X 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 42.0), Spleen (RPKM 37.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lnx2 in Genome Data Viewer
Location:
12p11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (13119139..13184401)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (8005202..8070494)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (9728415..9793428)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095852 Neighboring gene RNA polymerase I and III subunit D Neighboring gene uncharacterized LOC120095885 Neighboring gene uncharacterized LOC120095884 Neighboring gene mitochondrial translational initiation factor 3 Neighboring gene general transcription factor III A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the presynaptic glycine transporter GlyT2. de la Rocha-Muñoz A, et al. Sci Rep, 2019 Oct 18. PMID 31628376, Free PMC Article
  2. The Lnx family proteins function as molecular scaffolds for Numb family proteins. Rice DS, et al. Mol Cell Neurosci, 2001 Nov. PMID 11922143
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the presynaptic glycine transporter GlyT2.
    Title: E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the presynaptic glycine transporter GlyT2.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ligand of Numb protein X 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108329.1 → NP_001101799.1  ligand of Numb protein X 2

    See identical proteins and their annotated locations for NP_001101799.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474012
    UniProtKB/TrEMBL
    A0A8I6AEK4, A6K1B2, D3ZRH6
    Related
    ENSRNOP00000001263.3, ENSRNOT00000001263.5
    Conserved Domains (3) summary
    smart00228
    Location:229 → 315
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:595 → 679
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16780
    Location:46 → 90
    mRING-HC-C3HC3D_LNX2; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 2 (LNX2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    13119139..13184401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089547.2 → XP_038945475.1  ligand of Numb protein X 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AEK4, A6K1B2, D3ZRH6
    Conserved Domains (3) summary
    smart00228
    Location:229 → 315
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:595 → 679
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16780
    Location:46 → 90
    mRING-HC-C3HC3D_LNX2; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 2 (LNX2)

  2. XM_006248835.5 → XP_006248897.1  ligand of Numb protein X 2 isoform X1

    See identical proteins and their annotated locations for XP_006248897.1

    UniProtKB/TrEMBL
    A0A8I6AEK4, A6K1B2, D3ZRH6
    Conserved Domains (3) summary
    smart00228
    Location:229 → 315
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:595 → 679
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16780
    Location:46 → 90
    mRING-HC-C3HC3D_LNX2; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 2 (LNX2)

  3. XM_039089545.2 → XP_038945473.1  ligand of Numb protein X 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AEK4, A6K1B2, D3ZRH6
    Conserved Domains (3) summary
    smart00228
    Location:229 → 315
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:595 → 679
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16780
    Location:46 → 90
    mRING-HC-C3HC3D_LNX2; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 2 (LNX2)
Nucleotide Protein Strain
Heading Accession and Version

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