Zfand2a zinc finger AN1-type containing 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfand2aprovided by RGD
Official Full Name: zinc finger AN1-type containing 2Aprovided by RGD
Primary source: RGD:1310991
See related: EnsemblRapid:ENSRNOG00000032917 AllianceGenome:RGD:1310991
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310991
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein targeting to ER. Predicted to act upstream of or within cellular response to arsenic-containing substance and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of proteasome complex. Predicted to be active in endoplasmic reticulum. Orthologous to human ZFAND2A (zinc finger AN1-type containing 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 62.3), Lung (RPKM 60.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (20275435..20286513)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (15161601..15172679)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (17252093..17263477)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to arsenic-containing substance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to ER	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: AN1-type zinc finger protein 2A

Names: zinc finger, AN1-type domain 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008363.1 → NP_001008364.1 AN1-type zinc finger protein 2A

See identical proteins and their annotated locations for NP_001008364.1

Status: PROVISIONAL

Source sequence(s)

BC085928

UniProtKB/Swiss-Prot

Q5U2P3

UniProtKB/TrEMBL

A0A8L2QLB5, A6K1V4

Related

ENSRNOP00000043105.4, ENSRNOT00000047634.5

Conserved Domains (1) summary

pfam01428
Location:10 → 46

zf-AN1; AN1-like Zinc finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

20275435..20286513

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089558.1 → XP_038945486.1 AN1-type zinc finger protein 2A isoform X1

UniProtKB/Swiss-Prot

Q5U2P3

UniProtKB/TrEMBL

A0A8L2QLB5, A6K1V4

Conserved Domains (1) summary

pfam01428
Location:10 → 46

zf-AN1; AN1-like Zinc finger