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Rasal1 RAS protein activator like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360814, updated on 2-Nov-2024

Summary

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Official Symbol
Rasal1provided by RGD
Official Full Name
RAS protein activator like 1provided by RGD
Primary source
RGD:1311820
See related
EnsemblRapid:ENSRNOG00000001374 AllianceGenome:RGD:1311820
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in positive regulation of dendrite extension. Predicted to be located in cytosol and plasma membrane. Orthologous to human RASAL1 (RAS protein activator like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 63.8), Adrenal (RPKM 56.7) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rasal1 in Genome Data Viewer
Location:
12q16
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41541865..41574957, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35881269..35913727, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41416218..41449445, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase 2 Neighboring gene deltex E3 ubiquitin ligase 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A1, pseudogene 2 Neighboring gene cilia and flagella associated protein 73 Neighboring gene DEAD-box helicase 54

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in rats. Tao H, et al. Toxicology, 2011 Dec 18. PMID 22056649
  2. Paridis Rhizoma Sapoinins attenuates liver fibrosis in rats by regulating the expression of RASAL1/ERK1/2 signal pathway. Hong Y, et al. J Ethnopharmacol, 2016 Nov 4. PMID 27396351
  3. CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+. Liu Q, et al. J Cell Biol, 2005 Jul 18. PMID 16009725, Free PMC Article
  4. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. Yoo JC, et al. J Dermatol Sci, 2013 Dec. PMID 23999003

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Paridis rhizoma sapoinins attenuate CCl4-induced liver fibrosis through the regulation of RASAL1/ERK1/2 signal pathway.
    Title: Paridis Rhizoma Sapoinins attenuates liver fibrosis in rats by regulating the expression of RASAL1/ERK1/2 signal pathway.
  2. hypermethylation of RASAL1 is associated with the perpetuation of fibroblast activation and fibrogenesis in the liver
    Title: MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rasGAP-activating-like protein 1
Names
RAS protein activator like 1 (GAP1 like)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108335.1 → NP_001101805.1  rasGAP-activating-like protein 1

    See identical proteins and their annotated locations for NP_001101805.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473973
    UniProtKB/TrEMBL
    A6J1I2, D3ZHY9
    Related
    ENSRNOP00000001856.6, ENSRNOT00000001856.8
    Conserved Domains (6) summary
    cd05135
    Location:262 → 548
    RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
    smart00323
    Location:242 → 604
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam00169
    Location:566 → 672
    PH; PH domain
    pfam00779
    Location:681 → 708
    BTK; BTK motif
    cl14603
    Location:6 → 126
    C2; C2 domain
    cl17171
    Location:552 → 689
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    41541865..41574957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249395.5 → XP_006249457.1  rasGAP-activating-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006249457.1

    UniProtKB/TrEMBL
    A6J1I2, D3ZHY9
    Conserved Domains (6) summary
    cd05135
    Location:262 → 548
    RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
    smart00323
    Location:242 → 604
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam00169
    Location:566 → 672
    PH; PH domain
    pfam00779
    Location:681 → 708
    BTK; BTK motif
    cl14603
    Location:6 → 126
    C2; C2 domain
    cl17171
    Location:552 → 689
    PH-like; Pleckstrin homology-like domain

  2. XM_017598399.3 → XP_017453888.1  rasGAP-activating-like protein 1 isoform X3

    Conserved Domains (6) summary
    cd05135
    Location:80 → 366
    RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
    smart00323
    Location:60 → 422
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam00169
    Location:384 → 490
    PH; PH domain
    pfam00779
    Location:499 → 526
    BTK; BTK motif
    cl14603
    Location:33 → 72
    C2; C2 domain
    cl17171
    Location:370 → 507
    PH-like; Pleckstrin homology-like domain

  3. XM_039089599.2 → XP_038945527.1  rasGAP-activating-like protein 1 isoform X2

    Conserved Domains (3) summary
    pfam00779
    Location:323 → 350
    BTK; BTK motif
    cl02569
    Location:1 → 190
    RasGAP; Ras GTPase Activating Domain
    cl17171
    Location:194 → 331
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version

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