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Scyl3 SCY1 like pseudokinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360866, updated on 18-Sep-2024

Summary

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Official Symbol
Scyl3provided by RGD
Official Full Name
SCY1 like pseudokinase 3provided by RGD
Primary source
RGD:1308992
See related
EnsemblRapid:ENSRNOG00000025318 AllianceGenome:RGD:1308992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308992
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within cellular protein localization; inflammatory response; and neuron differentiation. Predicted to be located in Golgi membrane and lamellipodium. Orthologous to human SCYL3 (SCY1 like pseudokinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 94.6), Spleen (RPKM 70.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Scyl3 in Genome Data Viewer
Location:
13q23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (78811595..78836202)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (76278428..76303038)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (82230938..82255640)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene N-terminal Xaa-Pro-Lys N-methyltransferase 2 Neighboring gene kinesin-associated protein 3 Neighboring gene uncharacterized LOC120096301 Neighboring gene FIGNL1 interacting regulator of recombination and mitosis Neighboring gene uncharacterized LOC102555981 Neighboring gene methyltransferase 18, RPL3 N3(tau)-histidine Neighboring gene peptidylprolyl isomerase D, pseudogene 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PACE-1, a novel protein that interacts with the C-terminal domain of ezrin. Sullivan A, et al. Exp Cell Res, 2003 Apr 1. PMID 12651155
  2. Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability. Kuliyev E, et al. J Neurosci, 2018 Mar 7. PMID 29437892, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spinal cord motor neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein-associating with the carboxyl-terminal domain of ezrin
Names
SCY1-like 3
SCY1-like, kinase-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191828.2 → NP_001178757.1  protein-associating with the carboxyl-terminal domain of ezrin isoform 1

    See identical proteins and their annotated locations for NP_001178757.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6IDC6, D3ZK09
    Conserved Domains (3) summary
    pfam00069
    Location:26 → 245
    Pkinase; Protein kinase domain
    sd00044
    Location:256 → 283
    HEAT; HEAT repeat [structural motif]
    cl21453
    Location:9 → 247
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001429727.1 → NP_001416656.1  protein-associating with the carboxyl-terminal domain of ezrin isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  3. NM_001429728.1 → NP_001416657.1  protein-associating with the carboxyl-terminal domain of ezrin isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RNA

  1. NR_190778.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    78811595..78836202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769661.4 → XP_008767883.2  protein-associating with the carboxyl-terminal domain of ezrin isoform X2

    Related
    ENSRNOP00000003461.5, ENSRNOT00000003551.8

  2. XM_063272491.1 → XP_063128561.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X1

    UniProtKB/TrEMBL
    A6IDC6, D3ZK09

  3. XM_006250176.5 → XP_006250238.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X3

    See identical proteins and their annotated locations for XP_006250238.1

    Conserved Domains (2) summary
    sd00044
    Location:119 → 146
    HEAT; HEAT repeat [structural motif]
    cl21453
    Location:22 → 110
    PKc_like; Protein Kinases, catalytic domain

  4. XM_039090910.2 → XP_038946838.1  protein-associating with the carboxyl-terminal domain of ezrin isoform X4

    Conserved Domains (2) summary
    sd00044
    Location:114 → 141
    HEAT; HEAT repeat [structural motif]
    cl21453
    Location:1 → 105
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_005492254.2 RNA Sequence

  2. XR_005492255.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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