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Enah ENAH, actin regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 360891, updated on 2-Nov-2024

Summary

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Official Symbol
Enahprovided by RGD
Official Full Name
ENAH, actin regulatorprovided by RGD
Primary source
RGD:1307666
See related
EnsemblRapid:ENSRNOG00000031934 AllianceGenome:RGD:1307666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable SH3 domain binding activity; WW domain binding activity; and profilin binding activity. Involved in postsynaptic cytoskeleton organization. Is active in GABA-ergic synapse and postsynapse. Orthologous to human ENAH (ENAH actin regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 290.1), Heart (RPKM 226.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Enah in Genome Data Viewer
Location:
13q26
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (96149437..96269841, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (93617747..93738119, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (100297421..100415335, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L36a-like Neighboring gene lamin B receptor Neighboring gene signal recognition particle 9 Neighboring gene uncharacterized LOC108352583

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Selectivity in subunit composition of Ena/VASP tetramers. Riquelme DN, et al. Biosci Rep, 2015 Jul 28. PMID 26221026, Free PMC Article
  2. Mena associates with Rac1 and modulates connexin 43 remodeling in cardiomyocytes. Ram R, et al. Am J Physiol Heart Circ Physiol, 2014 Jan 1. PMID 24186093, Free PMC Article
  3. Enabled homolog (ENAH) regulated by RNA binding protein splicing factor 3b subunit 4 (SF3B4) exacerbates the proliferation, invasion and migration of hepatocellular carcinoma cells via Notch signaling pathway. Deng G, et al. Bioengineered, 2022 Feb. PMID 35030977, Free PMC Article
  4. Structural basis for polyproline recognition by the FE65 WW domain. Meiyappan M, et al. J Mol Biol, 2007 Sep 28. PMID 17686488, Free PMC Article
  5. Mena is required for neurulation and commissure formation. Lanier LM, et al. Neuron, 1999 Feb. PMID 10069337

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables profilin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables profilin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin polymerization-dependent cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin polymerization-dependent cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein enabled homolog
Names
enabled homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012150.2 → NP_001012150.1  protein enabled homolog isoform 2

    See identical proteins and their annotated locations for NP_001012150.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6JGK5, Q5XHX3
    Related
    ENSRNOP00000112465.1, ENSRNOT00000171057.1
    Conserved Domains (3) summary
    cd01207
    Location:25 → 132
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam06012
    Location:430 → 500
    DUF908; Domain of Unknown Function (DUF908)
    pfam08776
    Location:489 → 522
    VASP_tetra; VASP tetramerization domain

  2. NM_001401377.1 → NP_001388306.1  protein enabled homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I5ZT50, A6JGK6
    Related
    ENSRNOP00000081655.1, ENSRNOT00000098544.2

  3. NM_001415736.1 → NP_001402665.1  protein enabled homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    Related
    ENSRNOP00000081404.1, ENSRNOT00000097600.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    96149437..96269841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272503.1 → XP_063128573.1  protein enabled homolog isoform X11

  2. XM_063272502.1 → XP_063128572.1  protein enabled homolog isoform X10

  3. XM_063272500.1 → XP_063128570.1  protein enabled homolog isoform X9

  4. XM_063272497.1 → XP_063128567.1  protein enabled homolog isoform X6

    Related
    ENSRNOP00000109230.1, ENSRNOT00000153721.1

  5. XM_063272494.1 → XP_063128564.1  protein enabled homolog isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y4S4
    Related
    ENSRNOP00000076584.1, ENSRNOT00000109962.2

  6. XM_063272499.1 → XP_063128569.1  protein enabled homolog isoform X8

  7. XM_063272498.1 → XP_063128568.1  protein enabled homolog isoform X7

    UniProtKB/TrEMBL
    A0A0G2K6I4
    Related
    ENSRNOP00000073827.2, ENSRNOT00000085188.3

  8. XM_063272496.1 → XP_063128566.1  protein enabled homolog isoform X5

  9. XM_039090926.2 → XP_038946854.1  protein enabled homolog isoform X3

    UniProtKB/TrEMBL
    A0A8I6G5W6
    Conserved Domains (4) summary
    PLN03209
    Location:361 → 537
    PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
    cd01207
    Location:25 → 132
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:767 → 801
    VASP_tetra; VASP tetramerisation domain
    cd22185
    Location:619 → 645
    WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins

  10. XM_063272493.1 → XP_063128563.1  protein enabled homolog isoform X1

  11. XM_063272506.1 → XP_063128576.1  protein enabled homolog isoform X15

  12. XM_063272495.1 → XP_063128565.1  protein enabled homolog isoform X4

  13. XM_063272505.1 → XP_063128575.1  protein enabled homolog isoform X14

  14. XM_039090933.2 → XP_038946861.1  protein enabled homolog isoform X12

    Conserved Domains (2) summary
    pfam08776
    Location:405 → 439
    VASP_tetra; VASP tetramerisation domain
    cd22185
    Location:236 → 262
    WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins

  15. XM_063272504.1 → XP_063128574.1  protein enabled homolog isoform X13

Nucleotide Protein Strain
Heading Accession and Version

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