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Cops4 COP9 signalosome subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360915, updated on 2-Nov-2024

Summary

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Official Symbol
Cops4provided by RGD
Official Full Name
COP9 signalosome subunit 4provided by RGD
Primary source
RGD:1302952
See related
EnsemblRapid:ENSRNOG00000023650 AllianceGenome:RGD:1302952
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in protein deneddylation. Located in synaptic vesicle. Orthologous to human COPS4 (COP9 signalosome subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 374.8), Testes (RPKM 355.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cops4 in Genome Data Viewer
Location:
14p22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (9382897..9413216, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (9078579..9108788, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (10718863..10749134, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481703 Neighboring gene ubiquitin-conjugating enzyme E2 variant 2-like Neighboring gene placenta associated 8 Neighboring gene uncharacterized LOC102550950 Neighboring gene lin-54 DREAM MuvB core complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process. Granata A, et al. EMBO J, 2011 Jan 5. PMID 21102408, Free PMC Article
  2. Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Sharon M, et al. Structure, 2009 Jan 14. PMID 19141280
  3. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Wei N, et al. Curr Biol, 1998 Jul 30-Aug 13. PMID 9707402
  4. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. Fang L, et al. J Proteome Res, 2008 Nov. PMID 18850735, Free PMC Article
  5. Physiological Tau Interactome in Brain and Its Link to Tauopathies. Sinsky J, et al. J Proteome Res, 2020 Jun 5. PMID 32357304

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94896

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein deneddylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deneddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deneddylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IEA
Inferred from Electronic Annotation
more info
  
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 4
Names
COP9 (constitutive photomorphogenic) homolog, subunit 4
JAB1-containing signalosome subunit 4
SGN4
signalosome subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004275.1 → NP_001004275.1  COP9 signalosome complex subunit 4

    See identical proteins and their annotated locations for NP_001004275.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079384
    UniProtKB/Swiss-Prot
    Q68FS2
    UniProtKB/TrEMBL
    A0A8L2Q0P3, A6K5Z4
    Related
    ENSRNOP00000003046.5, ENSRNOT00000003046.8
    Conserved Domains (3) summary
    COG5071
    Location:71 → 377
    RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam18420
    Location:365 → 406
    CSN4_RPN5_eIF3a; CSN4/RPN5/eIF3a helix turn helix domain
    pfam01399
    Location:264 → 362
    PCI; PCI domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    9382897..9413216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273329.1 → XP_063129399.1  COP9 signalosome complex subunit 4 isoform X2

  2. XM_063273328.1 → XP_063129398.1  COP9 signalosome complex subunit 4 isoform X1

  3. XM_063273330.1 → XP_063129400.1  COP9 signalosome complex subunit 4 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FS2.1 GenPept UniProtKB/Swiss-Prot:Q68FS2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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