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Lnx1 ligand of numb-protein X 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360926, updated on 2-Nov-2024

Summary

Official Symbol
Lnx1provided by RGD
Official Full Name
ligand of numb-protein X 1provided by RGD
Primary source
RGD:1308159
See related
EnsemblRapid:ENSRNOG00000002272 AllianceGenome:RGD:1308159
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable PDZ domain binding activity; identical protein binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in synapse maturation and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm; hippocampal mossy fiber to CA3 synapse; and postsynapse. Orthologous to human LNX1 (ligand of numb-protein X 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 81.6), Kidney (RPKM 42.0) and 9 other tissues See more
Orthologs
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Genomic context

See Lnx1 in Genome Data Viewer
Location:
14p11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (33868517..33971217)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (33514429..33617086)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (36047136..36149740)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096595 Neighboring gene uncharacterized LOC134481742 Neighboring gene uncharacterized LOC134481839 Neighboring gene factor interacting with PAPOLA and CPSF1 Neighboring gene sec1 family domain containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene RAS-like family 11 member B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in synapse maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase LNX
Names
ligand of numb-protein X 1, E3 ubiquitin protein ligase
NP_001101828.1
XP_006250964.1
XP_006250965.1
XP_006250966.1
XP_038948102.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108358.1NP_001101828.1  E3 ubiquitin-protein ligase LNX

    See identical proteins and their annotated locations for NP_001101828.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473981
    UniProtKB/TrEMBL
    B6RHI5, B6RHI6, F7EWI3
    Related
    ENSRNOP00000003088.3, ENSRNOT00000003088.7
    Conserved Domains (3) summary
    smart00184
    Location:4581
    RING; Ring finger
    COG0265
    Location:260364
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:637721
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    33868517..33971217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092174.2XP_038948102.1  E3 ubiquitin-protein ligase LNX isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZXC4
    Conserved Domains (2) summary
    cd00992
    Location:276360
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd16779
    Location:4283
    mRING-HC-C3HC3D_LNX1; Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)
  2. XM_006250902.5XP_006250964.1  E3 ubiquitin-protein ligase LNX isoform X1

    UniProtKB/TrEMBL
    B6RHI5
    Conserved Domains (2) summary
    smart00184
    Location:4581
    RING; Ring finger
    cd00992
    Location:627711
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_006250903.5XP_006250965.1  E3 ubiquitin-protein ligase LNX isoform X2

    See identical proteins and their annotated locations for XP_006250965.1

    UniProtKB/TrEMBL
    A0A0G2JUI7, A6JD15, B6RHI7
    Related
    ENSRNOP00000069112.1, ENSRNOT00000082183.3
    Conserved Domains (1) summary
    cd00992
    Location:537621
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_006250904.5XP_006250966.1  E3 ubiquitin-protein ligase LNX isoform X3

    UniProtKB/TrEMBL
    B6RHI7
    Conserved Domains (1) summary
    cd00992
    Location:527611
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...