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Zswim8 zinc finger, SWIM-type containing 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361004, updated on 6-Jun-2024

Summary

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Symbol
Zswim8provided by RGD
Full Name
zinc finger, SWIM-type containing 8provided by RGD
Primary source
RGD:1309414
See related
Ensembl:ENSRNOG00000056617 AllianceGenome:RGD:1309414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309414
Summary
Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be involved in positive regulation of miRNA catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in cytosol. Predicted to be part of Cul2-RING ubiquitin ligase complex and Cul3-RING ubiquitin ligase complex. Orthologous to human ZSWIM8 (zinc finger SWIM-type containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 107.9), Lung (RPKM 95.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zswim8 in Genome Data Viewer
Location:
15p16
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (3623040..3638748, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (3573780..3589501, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (4006470..4022238, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352872 Neighboring gene calcium/calmodulin-dependent protein kinase II gamma Neighboring gene N-deacetylase and N-sulfotransferase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of miRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in target-directed miRNA degradation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of cullin-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger SWIM domain-containing protein 8
Names
zinc finger SWIM domain-containing protein 8-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271275.1 → NP_001258204.1  zinc finger SWIM domain-containing protein 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A0G2K9R0, D4A5A9
    Related
    ENSRNOP00000075092.1, ENSRNOT00000081997.2
    Conserved Domains (1) summary
    cl19527
    Location:131 → 263
    SWIM; SWIM zinc finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    3623040..3638748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274373.1 → XP_063130443.1  zinc finger SWIM domain-containing protein 8 isoform X9

    UniProtKB/TrEMBL
    A0A8I5Y637

  2. XM_063274370.1 → XP_063130440.1  zinc finger SWIM domain-containing protein 8 isoform X5

    UniProtKB/TrEMBL
    D4A5A9

  3. XM_063274369.1 → XP_063130439.1  zinc finger SWIM domain-containing protein 8 isoform X2

    UniProtKB/TrEMBL
    D4A5A9

  4. XM_008770549.4 → XP_008768771.1  zinc finger SWIM domain-containing protein 8 isoform X4

    UniProtKB/TrEMBL
    D4A5A9
    Conserved Domains (1) summary
    cl19527
    Location:131 → 263
    SWIM; SWIM zinc finger

  5. XM_008770548.4 → XP_008768770.1  zinc finger SWIM domain-containing protein 8 isoform X3

    UniProtKB/TrEMBL
    D4A5A9
    Conserved Domains (1) summary
    cl19527
    Location:131 → 263
    SWIM; SWIM zinc finger

  6. XM_008770546.4 → XP_008768768.1  zinc finger SWIM domain-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I6B124, D4A5A9
    Related
    ENSRNOP00000094531.1
    Conserved Domains (1) summary
    cl19527
    Location:131 → 263
    SWIM; SWIM zinc finger

  7. XM_063274371.1 → XP_063130441.1  zinc finger SWIM domain-containing protein 8 isoform X6

    UniProtKB/TrEMBL
    A6KKQ1

  8. XM_063274372.1 → XP_063130442.1  zinc finger SWIM domain-containing protein 8 isoform X7

  9. XM_039093435.2 → XP_038949363.1  zinc finger SWIM domain-containing protein 8 isoform X8

Nucleotide Protein Strain
Heading Accession and Version

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