Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mettl3provided by RGD
Official Full Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunitprovided by RGD
Primary source: RGD:1311750
See related: EnsemblRapid:ENSRNOG00000013111 AllianceGenome:RGD:1311750
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; mRNA m(6)A methyltransferase activity; and protein heterodimerization activity. Predicted to be involved in several processes, including RNA metabolic process; negative regulation of type I interferon-mediated signaling pathway; and regulation of gene expression. Predicted to be located in Golgi apparatus; cytosol; and nuclear speck. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in nucleus. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 182.3), Thymus (RPKM 157.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (27476659..27491134, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (25002505..25014097, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (28710299..28721491, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1.
Title: METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1.
Methyltransferase METTL3 regulates neuropathic pain through m6A methylation modification of SOCS1.
Title: Methyltransferase METTL3 regulates neuropathic pain through m6A methylation modification of SOCS1.
METTL3 mediated ferroptosis in chondrocytes and promoted pain in KOA via HMGB1 m6A modification.
Title: METTL3 mediated ferroptosis in chondrocytes and promoted pain in KOA via HMGB1 m6A modification.
miR-340-3p-modified bone marrow mesenchymal stem cell-derived exosomes inhibit ferroptosis through METTL3-mediated m[6]A modification of HMOX1 to promote recovery of injured rat uterus.
Title: miR-340-3p-modified bone marrow mesenchymal stem cell-derived exosomes inhibit ferroptosis through METTL3-mediated m(6)A modification of HMOX1 to promote recovery of injured rat uterus.
METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m[6]A modification.
Title: METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m(6)A modification.
METTL3 Mediates Microglial Activation and Blood-Brain Barrier Permeability in Cerebral Ischemic Stroke by Regulating NLRP3 Inflammasomes Through m6A Methylation Modification.
Title: METTL3 Mediates Microglial Activation and Blood-Brain Barrier Permeability in Cerebral Ischemic Stroke by Regulating NLRP3 Inflammasomes Through m6A Methylation Modification.
m6A methyltransferase METTL3 contributes to sympathetic hyperactivity post-MI via promoting TRAF6-dependent mitochondrial ROS production.
Title: m6A methyltransferase METTL3 contributes to sympathetic hyperactivity post-MI via promoting TRAF6-dependent mitochondrial ROS production.
METTL3-mediated maturation of miR-192-5p targets ATG7 to prevent Schwann cell autophagy in peripheral nerve injury.
Title: METTL3-mediated maturation of miR-192-5p targets ATG7 to prevent Schwann cell autophagy in peripheral nerve injury.
METTL3 achieves lipopolysaccharide-induced myocardial injury via m[6]A-dependent stabilization of Myh3 mRNA.
Title: METTL3 achieves lipopolysaccharide-induced myocardial injury via m(6)A-dependent stabilization of Myh3 mRNA.
METTL3-dependent m6A modification mediates bladder remodeling after partial bladder outlet obstruction through CCN2 activation.
Title: METTL3-dependent m6A modification mediates bladder remodeling after partial bladder outlet obstruction through CCN2 activation.

Submit: New GeneRIF Correction See all GeneRIFs (30)

General gene information

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Markers

AU024844 (e-PCR)
- UniSTS:115847

RH133738 (e-PCR)
- UniSTS:217021

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables S-adenosyl-L-methionine binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA m(6)A methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA m(6)A methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in RNA methylation	ISO Inferred from Sequence Orthology more info
involved_in adenosine to inosine editing	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in dosage compensation by inactivation of X chromosome	ISO Inferred from Sequence Orthology more info
involved_in forebrain radial glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in gliogenesis	ISO Inferred from Sequence Orthology more info
involved_in mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA modification	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
NOT involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in oogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cap-independent translational initiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in primary miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in stem cell population maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of RNA N6-methyladenosine methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA N6-methyladenosine methyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: N6-adenosine-methyltransferase catalytic subunit

Names: N6-adenosine-methyltransferase 70 kDa subunit; methyltransferase-like 3

NP_001019965.1

EC 2.1.1.62

XP_008768777.1

EC 2.1.1.62

XP_038949409.1

EC 2.1.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024794.1 → NP_001019965.1 N6-adenosine-methyltransferase catalytic subunit

See identical proteins and their annotated locations for NP_001019965.1

Status: PROVISIONAL

Source sequence(s)

BC097400

UniProtKB/TrEMBL

Q4V8G6

Related

ENSRNOP00000017720.6, ENSRNOT00000017720.9

Conserved Domains (1) summary

pfam05063
Location:389 → 550

MT-A70

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

27476659..27491134 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008770555.4 → XP_008768777.1 N6-adenosine-methyltransferase catalytic subunit isoform X1

UniProtKB/TrEMBL

F7FFC6

Conserved Domains (1) summary

pfam05063
Location:389 → 544

MT-A70
XM_039093481.2 → XP_038949409.1 N6-adenosine-methyltransferase catalytic subunit isoform X2

Conserved Domains (1) summary

pfam05063
Location:234 → 395

MT-A70