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Carmil3 capping protein regulator and myosin 1 linker 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361041, updated on 2-Nov-2024

Summary

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Official Symbol
Carmil3provided by RGD
Official Full Name
capping protein regulator and myosin 1 linker 3provided by RGD
Primary source
RGD:1359120
See related
EnsemblRapid:ENSRNOG00000025518 AllianceGenome:RGD:1359120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lrrc16b
Summary
Predicted to be involved in cell migration; regulation of Arp2/3 complex-mediated actin nucleation; and regulation of postsynapse assembly. Predicted to be located in cytoplasm. Predicted to be active in several cellular components, including glutamatergic synapse; lamellipodium; and postsynapse. Orthologous to human CARMIL3 (capping protein regulator and myosin 1 linker 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 41.2), Heart (RPKM 25.4) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Carmil3 in Genome Data Viewer
Location:
15p13
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32948228..32965829)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28978440..28995865)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34167146..34184799)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S17, pseudogene 8 Neighboring gene dehydrogenase/reductase 4 Neighboring gene uncharacterized LOC102552093 Neighboring gene copine 6 Neighboring gene neural retina leucine zipper

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cell Migration and Invadopodia Formation Require a Membrane-binding Domain of CARMIL2. Lanier MH, et al. J Biol Chem, 2016 Jan 15. PMID 26578515, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynapse assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
capping protein, Arp2/3 and myosin-I linker protein 3
Names
capping protein regulator and myosin 1 linker protein 3
leucine rich repeat containing 16B
leucine-rich repeat-containing protein 16B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014138.3 → NP_001014160.2  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A0H2UHV1
    Conserved Domains (4) summary
    cd00116
    Location:339 → 600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:275 → 303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245 → 273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:778 → 1062
    CARMIL_C; CARMIL C-terminus

  2. NM_001431678.1 → NP_001418607.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  3. NM_001431679.1 → NP_001418608.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  4. NM_001431680.1 → NP_001418609.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    32948228..32965829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008770681.4 → XP_008768903.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X1

    Related
    ENSRNOP00000036263.7, ENSRNOT00000032252.7
    Conserved Domains (4) summary
    cd00116
    Location:339 → 600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:275 → 303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245 → 273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:778 → 1062
    CARMIL_C; CARMIL C-terminus

  2. XM_008770682.4 → XP_008768904.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHV1
    Conserved Domains (4) summary
    cd00116
    Location:339 → 600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:275 → 303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245 → 273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:778 → 1062
    CARMIL_C; CARMIL C-terminus

  3. XM_008770683.4 → XP_008768905.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X3

    Conserved Domains (4) summary
    cd00116
    Location:339 → 600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:275 → 303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245 → 273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:778 → 1062
    CARMIL_C; CARMIL C-terminus

  4. XM_063274405.1 → XP_063130475.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X5

  5. XM_063274404.1 → XP_063130474.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X4

  6. XM_008770684.4 → XP_008768906.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X6

    Conserved Domains (4) summary
    cd00116
    Location:339 → 600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:275 → 303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245 → 273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:778 → 1062
    CARMIL_C; CARMIL C-terminus

  7. XM_008770685.4 → XP_008768907.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X7

    See identical proteins and their annotated locations for XP_008768907.1

    UniProtKB/Swiss-Prot
    Q5XHY1
    UniProtKB/TrEMBL
    A0A0H2UHV1
    Conserved Domains (4) summary
    cd00116
    Location:339 → 600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:275 → 303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245 → 273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:778 → 1062
    CARMIL_C; CARMIL C-terminus

  8. XM_063274406.1 → XP_063130476.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X8

  9. XM_008770687.4 → XP_008768909.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X9

    UniProtKB/TrEMBL
    A0A0H2UHV1
    Conserved Domains (4) summary
    cd00116
    Location:246 → 507
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:182 → 210
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:152 → 180
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:685 → 969
    CARMIL_C; CARMIL C-terminus

  10. XM_039093487.2 → XP_038949415.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X10

    Conserved Domains (1) summary
    pfam16000
    Location:198 → 482
    CARMIL_C; CARMIL C-terminus

  11. XM_039093488.2 → XP_038949416.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X11

    Conserved Domains (1) summary
    pfam16000
    Location:110 → 394
    CARMIL_C; CARMIL C-terminus

RNA

  1. XR_005493761.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XHY1.2 GenPept UniProtKB/Swiss-Prot:Q5XHY1

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