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Rnaseh2b ribonuclease H2, subunit B [ Rattus norvegicus (Norway rat) ]

Gene ID: 361056, updated on 10-Oct-2024

Summary

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Official Symbol
Rnaseh2bprovided by RGD
Official Full Name
ribonuclease H2, subunit Bprovided by RGD
Primary source
RGD:1359710
See related
EnsemblRapid:ENSRNOG00000009192 AllianceGenome:RGD:1359710
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in RNA catabolic process and ribonucleotide metabolic process. Predicted to act upstream of or within several processes, including in utero embryonic development; positive regulation of fibroblast proliferation; and regulation of cell cycle phase transition. Predicted to be part of ribonuclease H2 complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2B (ribonuclease H2 subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 271.9), Spleen (RPKM 78.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnaseh2b in Genome Data Viewer
Location:
15p12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (40717252..40770826)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (36541200..36592016)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (45422010..45472792)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547888 Neighboring gene deleted in lymphocytic leukemia, 7 Neighboring gene uncharacterized LOC120097007 Neighboring gene guanylate cyclase 1 soluble subunit beta 2 Neighboring gene similar to human chromosome 13 open reading frame 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières syndrome defects. Figiel M, et al. J Biol Chem, 2011 Mar 25. PMID 21177858, Free PMC Article
  2. The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction. Shaban NM, et al. J Biol Chem, 2010 Feb 5. PMID 19923215, Free PMC Article
  3. Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity. Hiller B, et al. J Exp Med, 2012 Jul 30. PMID 22802351, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94780

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA damage checkpoint IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in ribonucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ribonucleotide metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of ribonuclease H2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease H2 complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease H2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonuclease H2 complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ribonuclease H2 subunit B
Names
RNase H2 subunit B
ribonuclease HI subunit B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007007.1 → NP_001007008.1  ribonuclease H2 subunit B

    See identical proteins and their annotated locations for NP_001007008.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083791
    UniProtKB/Swiss-Prot
    Q5XI96
    UniProtKB/TrEMBL
    A0A8L2Q5D7, A6K6C8
    Related
    ENSRNOP00000012231.6, ENSRNOT00000012231.6
    Conserved Domains (1) summary
    cd09270
    Location:16 → 298
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    40717252..40770826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274421.1 → XP_063130491.1  ribonuclease H2 subunit B isoform X12

  2. XM_039093506.2 → XP_038949434.1  ribonuclease H2 subunit B isoform X4

    UniProtKB/TrEMBL
    A0A8L2Q5D7
    Related
    ENSRNOP00000103384.1, ENSRNOT00000145208.1
    Conserved Domains (1) summary
    cd09270
    Location:16 → 274
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

  3. XM_063274419.1 → XP_063130489.1  ribonuclease H2 subunit B isoform X9

    Related
    ENSRNOP00000110574.1, ENSRNOT00000122637.1

  4. XM_063274420.1 → XP_063130490.1  ribonuclease H2 subunit B isoform X11

  5. XM_063274417.1 → XP_063130487.1  ribonuclease H2 subunit B isoform X7

    Related
    ENSRNOP00000104857.1, ENSRNOT00000148528.1

  6. XM_063274416.1 → XP_063130486.1  ribonuclease H2 subunit B isoform X3

  7. XM_039093508.2 → XP_038949436.1  ribonuclease H2 subunit B isoform X10

    UniProtKB/TrEMBL
    A6K6C9
    Conserved Domains (1) summary
    cd09270
    Location:30 → 171
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

  8. XM_039093505.2 → XP_038949433.1  ribonuclease H2 subunit B isoform X2

    UniProtKB/TrEMBL
    A0A8L2Q5D7
    Conserved Domains (1) summary
    cd09270
    Location:30 → 298
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

  9. XM_008770764.4 → XP_008768986.1  ribonuclease H2 subunit B isoform X6

    UniProtKB/TrEMBL
    A0A8L2Q5D7
    Conserved Domains (1) summary
    cd09270
    Location:30 → 272
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

  10. XM_039093507.2 → XP_038949435.1  ribonuclease H2 subunit B isoform X5

    UniProtKB/TrEMBL
    A0A8L2Q5D7
    Conserved Domains (1) summary
    cd09270
    Location:30 → 171
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

  11. XM_008770765.4 → XP_008768987.1  ribonuclease H2 subunit B isoform X8

    UniProtKB/TrEMBL
    A6K6C9
    Conserved Domains (1) summary
    cd09270
    Location:30 → 171
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

  12. XM_008770762.4 → XP_008768984.1  ribonuclease H2 subunit B isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q5D7
    Related
    ENSRNOP00000099248.1, ENSRNOT00000164657.1
    Conserved Domains (1) summary
    cd09270
    Location:30 → 299
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

  13. XM_039093509.1 → XP_038949437.1  ribonuclease H2 subunit B isoform X13

    Conserved Domains (1) summary
    cd09270
    Location:1 → 209
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XI96.1 GenPept UniProtKB/Swiss-Prot:Q5XI96

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