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Ints6 integrator complex subunit 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361057, updated on 10-Oct-2024

Summary

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Symbol
Ints6provided by RGD
Full Name
integrator complex subunit 6provided by RGD
Primary source
RGD:1309480
See related
EnsemblRapid:ENSRNOG00000009873 AllianceGenome:RGD:1309480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ddx26; LRRGT00024
Summary
Predicted to be involved in snRNA 3'-end processing. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be part of integrator complex. Orthologous to human INTS6 (integrator complex subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 149.9), Thymus (RPKM 141.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ints6 in Genome Data Viewer
Location:
15p12
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (41080584..41224350, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (36908966..37048043, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (45844050..45929996, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482129 Neighboring gene family with sequence similarity 124 member A Neighboring gene small nucleolar RNA SNORA17 Neighboring gene serpin family E member 3 Neighboring gene ribosomal protein L38, pseudogene 7 Neighboring gene Sec61 translocon subunit gamma, pseudogene 5 Neighboring gene zinc finger CCCH domain-containing protein 13-like Neighboring gene large ribosomal subunit protein eL27-like Neighboring gene WD repeat and FYVE domain containing 2 Neighboring gene uncharacterized LOC120097010 Neighboring gene ribosomal protein L23a, pseudogene 2 Neighboring gene defensin beta 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
  2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, et al. Cell, 2005 Oct 21. PMID 16239144
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
integrator complex subunit 6
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271488.1 → NP_001258417.1  integrator complex subunit 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8I6AP01, A6K6E2
    Related
    ENSRNOP00000095908.1, ENSRNOT00000101257.2
    Conserved Domains (2) summary
    pfam13519
    Location:4 → 103
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:805 → 864
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    41080584..41224350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274427.1 → XP_063130497.1  integrator complex subunit 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AP01

  2. XM_063274428.1 → XP_063130498.1  integrator complex subunit 6 isoform X2

  3. XM_063274426.1 → XP_063130496.1  integrator complex subunit 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AP01

  4. XM_003751499.6 → XP_003751547.1  integrator complex subunit 6 isoform X2

    UniProtKB/TrEMBL
    A6K6E2
    Conserved Domains (2) summary
    cd00198
    Location:4 → 131
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam15300
    Location:795 → 854
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  5. XM_039093511.2 → XP_038949439.1  integrator complex subunit 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AP01, A6K6E2
    Conserved Domains (2) summary
    pfam13519
    Location:4 → 103
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:805 → 864
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  6. XM_063274423.1 → XP_063130493.1  integrator complex subunit 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AP01

  7. XM_063274422.1 → XP_063130492.1  integrator complex subunit 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AP01

  8. XM_063274425.1 → XP_063130495.1  integrator complex subunit 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AP01

  9. XM_063274424.1 → XP_063130494.1  integrator complex subunit 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AP01

RNA

  1. XR_005493766.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001047904.1: Suppressed sequence

    Description
    NM_001047904.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: INTS6 (GeneID:26512).
Nucleotide Protein Strain
Heading Accession and Version

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