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Dgkh diacylglycerol kinase, eta [ Rattus norvegicus (Norway rat) ]

Gene ID: 361076, updated on 2-Nov-2024

Summary

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Official Symbol
Dgkhprovided by RGD
Official Full Name
diacylglycerol kinase, etaprovided by RGD
Primary source
RGD:1561955
See related
EnsemblRapid:ENSRNOG00000010065 AllianceGenome:RGD:1561955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561955
Summary
Predicted to enable several functions, including ATP-dependent diacylglycerol kinase activity; SAM domain binding activity; and identical protein binding activity. Predicted to be involved in glycerolipid metabolic process; lipid phosphorylation; and phospholipase C/protein kinase C signal transduction. Predicted to be located in actin cytoskeleton and endosome. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Orthologous to human DGKH (diacylglycerol kinase eta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 108.2), Brain (RPKM 78.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dgkh in Genome Data Viewer
Location:
15q11
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (60390279..60559777, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (53981079..54150470, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (60791574..60967236, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549816 Neighboring gene uncharacterized LOC120097049 Neighboring gene A-kinase anchoring protein 11 Neighboring gene uncharacterized LOC108353040 Neighboring gene uncharacterized LOC120097120 Neighboring gene von Willebrand factor A domain containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of two splice variants of human diacylglycerol kinase eta. Murakami T, et al. J Biol Chem, 2003 Sep 5. PMID 12810723
  2. Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method. Sato M, et al. Pharmacology, 2013. PMID 23949095
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables SAM domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in diacylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C/protein kinase C signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C/protein kinase C signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
diacylglycerol kinase eta
XP_006252425.1
XP_008769142.1
XP_038949963.2
XP_038949964.2
XP_038949966.1
XP_063130509.1
XP_063130510.1
XP_063130511.1
XP_063130512.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427603.2 → NP_001414532.2  diacylglycerol kinase eta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    Related
    ENSRNOP00000077411.2, ENSRNOT00000097320.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    60390279..60559777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094036.2 → XP_038949964.2  diacylglycerol kinase eta isoform X2

    Related
    ENSRNOP00000054887.5, ENSRNOT00000058079.6

  2. XM_063274439.1 → XP_063130509.1  diacylglycerol kinase eta isoform X3

  3. XM_039094035.2 → XP_038949963.2  diacylglycerol kinase eta isoform X1

  4. XM_008770920.4 → XP_008769142.1  diacylglycerol kinase eta isoform X4

    See identical proteins and their annotated locations for XP_008769142.1

    UniProtKB/TrEMBL
    D3ZSZ6
    Conserved Domains (5) summary
    cd09576
    Location:1005 → 1069
    SAM_DGK-eta; SAM domain of diacylglycerol kinase eta
    smart00045
    Location:628 → 785
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:198 → 320
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd20848
    Location:11 → 96
    C1_DGKeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase eta (DAG kinase eta) and similar proteins
    cd20894
    Location:107 → 168
    C1_DGKeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase eta (DAG kinase eta) and similar proteins

  5. XM_006252363.5 → XP_006252425.1  diacylglycerol kinase eta isoform X4

    See identical proteins and their annotated locations for XP_006252425.1

    UniProtKB/TrEMBL
    D3ZSZ6
    Conserved Domains (5) summary
    cd09576
    Location:1005 → 1069
    SAM_DGK-eta; SAM domain of diacylglycerol kinase eta
    smart00045
    Location:628 → 785
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:198 → 320
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd20848
    Location:11 → 96
    C1_DGKeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase eta (DAG kinase eta) and similar proteins
    cd20894
    Location:107 → 168
    C1_DGKeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase eta (DAG kinase eta) and similar proteins

  6. XM_039094038.2 → XP_038949966.1  diacylglycerol kinase eta isoform X4

    UniProtKB/TrEMBL
    D3ZSZ6
    Conserved Domains (5) summary
    cd09576
    Location:1005 → 1069
    SAM_DGK-eta; SAM domain of diacylglycerol kinase eta
    smart00045
    Location:628 → 785
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:198 → 320
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd20848
    Location:11 → 96
    C1_DGKeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase eta (DAG kinase eta) and similar proteins
    cd20894
    Location:107 → 168
    C1_DGKeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase eta (DAG kinase eta) and similar proteins

  7. XM_063274440.1 → XP_063130510.1  diacylglycerol kinase eta isoform X4

  8. XM_063274441.1 → XP_063130511.1  diacylglycerol kinase eta isoform X4

  9. XM_063274442.1 → XP_063130512.1  diacylglycerol kinase eta isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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