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Prxl2a peroxiredoxin like 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 361118, updated on 28-Oct-2024

Summary

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Official Symbol
Prxl2aprovided by RGD
Official Full Name
peroxiredoxin like 2Aprovided by RGD
Primary source
RGD:1309676
See related
EnsemblRapid:ENSRNOG00000011140 AllianceGenome:RGD:1309676
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PAMM; Fam213a; RGD1309676
Summary
Predicted to enable antioxidant activity. Predicted to be involved in regulation of osteoclast differentiation. Predicted to be located in extracellular region and membrane. Predicted to be active in cytoplasm. Orthologous to human PRXL2A (peroxiredoxin like 2A). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Testes (RPKM 447.1), Adrenal (RPKM 340.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prxl2a in Genome Data Viewer
Location:
16p14
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (16900697..16920521, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (16866601..16886378, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (17494000..17513781)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 4B Neighboring gene tetraspanin 14 Neighboring gene DPY30 domain containing 2 Neighboring gene DPY30 domain containing 1 Neighboring gene transfer RNA alanine (anticodon AGC) 72 Neighboring gene methionine adenosyltransferase 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PAMM: a redox regulatory protein that modulates osteoclast differentiation. Xu Y, et al. Antioxid Redox Signal, 2010 Jul 1. PMID 19951071, Free PMC Article
  2. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables antioxidant activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
  
enables antioxidant activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peroxiredoxin-like 2A
Names
UPF0765 protein C10orf58 homolog
family with sequence similarity 213, member A
peroxiredoxin-like 2 activated in M-CSF stimulated monocytes
redox-regulatory protein FAM213A
redox-regulatory protein PAMM
sperm head protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014140.1 → NP_001014162.1  peroxiredoxin-like 2A

    See identical proteins and their annotated locations for NP_001014162.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079275
    UniProtKB/Swiss-Prot
    P85300, Q6AXX6
    UniProtKB/TrEMBL
    A6K9L0
    Related
    ENSRNOP00000078597.1, ENSRNOT00000113272.2
    Conserved Domains (1) summary
    cd02970
    Location:48 → 201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    16900697..16920521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275493.1 → XP_063131563.1  peroxiredoxin-like 2A isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q6Y2
    Related
    ENSRNOP00000014819.5, ENSRNOT00000014819.7

  2. XM_006252791.5 → XP_006252853.1  peroxiredoxin-like 2A isoform X2

    See identical proteins and their annotated locations for XP_006252853.1

    UniProtKB/Swiss-Prot
    P85300, Q6AXX6
    UniProtKB/TrEMBL
    A6K9L0
    Related
    ENSRNOP00000102558.1, ENSRNOT00000158328.1
    Conserved Domains (1) summary
    cd02970
    Location:48 → 201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXX6.1 GenPept UniProtKB/Swiss-Prot:Q6AXX6

Gene LinkOut

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