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Asb5 ankyrin repeat and SOCS box-containing 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361187, updated on 2-Nov-2024

Summary

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Official Symbol
Asb5provided by RGD
Official Full Name
ankyrin repeat and SOCS box-containing 5provided by RGD
Primary source
RGD:1565973
See related
EnsemblRapid:ENSRNOG00000042630 AllianceGenome:RGD:1565973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in positive regulation of protein catabolic process and protein ubiquitination. Predicted to be located in membrane. Orthologous to human ASB5 (ankyrin repeat and SOCS box containing 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 160.4), Heart (RPKM 11.9) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Asb5 in Genome Data Viewer
Location:
16p11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (43970940..44038318, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (37237869..37305207, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (39985233..40050663, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 17 Neighboring gene spermatogenesis associated 4 Neighboring gene signal peptidase complex subunit 3 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC114420

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044247.2 → NP_001037712.1  ankyrin repeat and SOCS box protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001037712.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6A894, D4A0S9, Q4KLY9
    Conserved Domains (5) summary
    cd00204
    Location:71 → 188
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03724
    Location:273 → 314
    SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
    pfam12796
    Location:74 → 165
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:218 → 267
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:71 → 100
    ANK; ANK repeat [structural motif]

  2. NM_001399413.1 → NP_001386342.1  ankyrin repeat and SOCS box protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8J8XZ77, A6JPH2
    Related
    ENSRNOP00000061114.3, ENSRNOT00000066639.5
    Conserved Domains (3) summary
    PHA02876
    Location:72 → 288
    PHA02876; ankyrin repeat protein; Provisional
    cd03724
    Location:288 → 329
    SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
    sd00045
    Location:71 → 100
    ANK; ANK repeat [structural motif]

  3. NM_001399414.1 → NP_001386343.1  ankyrin repeat and SOCS box protein 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    Related
    ENSRNOP00000088645.2, ENSRNOT00000103090.2
    Conserved Domains (3) summary
    cd03724
    Location:243 → 284
    SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
    sd00045
    Location:71 → 100
    ANK; ANK repeat [structural motif]
    cl39094
    Location:73 → 244
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    43970940..44038318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275582.1 → XP_063131652.1  ankyrin repeat and SOCS box protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8J8XZ77, A6JPH2

  2. XM_017600190.3 → XP_017455679.1  ankyrin repeat and SOCS box protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A894, A0A8J8XZ77, A6JPH2
    Conserved Domains (3) summary
    PHA02876
    Location:72 → 288
    PHA02876; ankyrin repeat protein; Provisional
    cd03724
    Location:288 → 329
    SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
    sd00045
    Location:71 → 100
    ANK; ANK repeat [structural motif]

  3. XM_039094701.2 → XP_038950629.1  ankyrin repeat and SOCS box protein 5 isoform X6

    Conserved Domains (3) summary
    PHA02876
    Location:19 → 235
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:18 → 47
    ANK; ANK repeat [structural motif]
    cl02533
    Location:235 → 276
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  4. XM_039094698.2 → XP_038950626.1  ankyrin repeat and SOCS box protein 5 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A894, A0A8I6GE39
    Related
    ENSRNOP00000086492.1, ENSRNOT00000116663.2
    Conserved Domains (3) summary
    cd03724
    Location:265 → 306
    SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
    sd00045
    Location:48 → 77
    ANK; ANK repeat [structural motif]
    cl39094
    Location:50 → 266
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_008771248.4 → XP_008769470.1  ankyrin repeat and SOCS box protein 5 isoform X5

    UniProtKB/TrEMBL
    A0A0G2K854
    Related
    ENSRNOP00000074476.2, ENSRNOT00000089665.3
    Conserved Domains (4) summary
    cd00204
    Location:26 → 143
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03724
    Location:243 → 284
    SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
    pfam12796
    Location:29 → 120
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:26 → 55
    ANK; ANK repeat [structural motif]

  6. XM_039094699.2 → XP_038950627.1  ankyrin repeat and SOCS box protein 5 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A894
    Related
    ENSRNOP00000103447.1, ENSRNOT00000162968.1
    Conserved Domains (3) summary
    cd03724
    Location:258 → 299
    SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
    sd00045
    Location:41 → 70
    ANK; ANK repeat [structural motif]
    cl39094
    Location:26 → 259
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_039094697.2 → XP_038950625.1  ankyrin repeat and SOCS box protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A894
    Conserved Domains (3) summary
    cd03724
    Location:266 → 307
    SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
    sd00045
    Location:49 → 78
    ANK; ANK repeat [structural motif]
    cl39094
    Location:34 → 267
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version

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