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Nsun2 NOP2/Sun RNA methyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361191, updated on 10-Jul-2024

Summary

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Official Symbol
Nsun2provided by RGD
Official Full Name
NOP2/Sun RNA methyltransferase 2provided by RGD
Primary source
RGD:1311954
See related
EnsemblRapid:ENSRNOG00000017254 AllianceGenome:RGD:1311954
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311954
Summary
Predicted to enable mRNA (cytidine-5-)-methyltransferase activity; tRNA (cytosine-5-)-methyltransferase activity; and tRNA binding activity. Predicted to be involved in several processes, including RNA methylation; regulation of mRNA export from nucleus; and tRNA stabilization. Predicted to act upstream of or within hair follicle maturation and in utero embryonic development. Predicted to be located in several cellular components, including chromatoid body; extracellular exosome; and nucleolus. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 162.8), Spleen (RPKM 160.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nsun2 in Genome Data Viewer
Location:
1p11
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (35490583..35514839, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (33662139..33685887, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (36295650..36319906, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 QL1 Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene steroid 5 alpha-reductase 1 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene Rab geranylgeranyltransferase subunit beta, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Homocysteine upregulates interleukin-17A expression via NSun2-mediated RNA methylation in T lymphocytes. Wang N, et al. Biochem Biophys Res Commun, 2017 Nov 4. PMID 28919411
  2. NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1. Luo Y, et al. Circ Res, 2016 Mar 18. PMID 26838785
  3. Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs. Shinoda S, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31287866, Free PMC Article
  4. NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs. Van Haute L, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31276587, Free PMC Article
  5. NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs. Hussain S, et al. Cell Rep, 2013 Jul 25. PMID 23871666, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In conclusion, NSun2 mediates HHcy-induced upregulation of IL-17A expression by methylating IL-17A mRNA and promoting its translation in T lymphocytes.
    Title: Homocysteine upregulates interleukin-17A expression via NSun2-mediated RNA methylation in T lymphocytes.
  2. Nsun2 up-regulates the expression of ICAM-1 in vascular endothelium by methylation of ICAM-1 mRNA.
    Title: NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA (cytidine-5-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA (cytidine-5-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA (cytidine-5-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hair follicle maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in hair follicle maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic cell cycle checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatoid body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA cytosine C(5)-methyltransferase NSUN2
Names
NOL1/NOP2/Sun domain family, member 2
NOP2/Sun RNA methyltransferase family, member 2
NOP2/Sun domain family, member 2
tRNA (cytosine(34)-C(5))-methyltransferase
tRNA (cytosine-5-)-methyltransferase NSUN2
NP_001101873.1
XP_006227854.1
XP_063122019.1
XP_063122020.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108403.1 → NP_001101873.1  RNA cytosine C(5)-methyltransferase NSUN2

    See identical proteins and their annotated locations for NP_001101873.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474002
    UniProtKB/TrEMBL
    A0A0G2JUK0, A6JV18, D4A3S8
    Related
    ENSRNOP00000023641.5, ENSRNOT00000023641.8
    Conserved Domains (2) summary
    TIGR00446
    Location:103 → 454
    nop2p; NOL1/NOP2/sun family putative RNA methylase
    cl17173
    Location:194 → 452
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    35490583..35514839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265950.1 → XP_063122020.1  RNA cytosine C(5)-methyltransferase NSUN2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUK0, A6JV18, D4A3S8

  2. XM_063265949.1 → XP_063122019.1  RNA cytosine C(5)-methyltransferase NSUN2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUK0, A6JV18, D4A3S8

  3. XM_006227792.5 → XP_006227854.1  RNA cytosine C(5)-methyltransferase NSUN2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JUK0
    Related
    ENSRNOP00000101574.1, ENSRNOT00000161739.1
    Conserved Domains (2) summary
    TIGR00446
    Location:103 → 430
    nop2p; NOL1/NOP2/sun family putative RNA methylase
    cl17173
    Location:177 → 428
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein Strain
Heading Accession and Version

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