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Svil supervillin [ Rattus norvegicus (Norway rat) ]

Gene ID: 361256, updated on 17-Aug-2024

Summary

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Official Symbol
Svilprovided by RGD
Official Full Name
supervillinprovided by RGD
Primary source
RGD:1306354
See related
EnsemblRapid:ENSRNOG00000018110 AllianceGenome:RGD:1306354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to be located in several cellular components, including costamere; cytosol; and nucleus. Predicted to be active in actin cytoskeleton and cytoplasm. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 505.9), Heart (RPKM 236.6) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
17q12.1
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (57343910..57539508, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (52648502..52844114, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (55230298..55425967, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 438 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 like 3 Neighboring gene uncharacterized LOC108348573 Neighboring gene uncharacterized LOC120097826 Neighboring gene ribosomal protein S24, pseudogene 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton. Oh SW, et al. J Cell Sci, 2003 Jun 1. PMID 12711699
  2. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article
  3. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in costamere ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
supervillin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108416.3 → NP_001101886.2  supervillin

    See identical proteins and their annotated locations for NP_001101886.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A8I6A8S3, F1M155
    Related
    ENSRNOP00000025037.7, ENSRNOT00000025037.10
    Conserved Domains (6) summary
    smart00153
    Location:2130 → 2165
    VHP; Villin headpiece domain
    cd11280
    Location:1514 → 1614
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1830 → 1935
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1393 → 1489
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1697 → 1810
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1952 → 2074
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    57343910..57539508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254030.5 → XP_006254092.1  supervillin isoform X8

    See identical proteins and their annotated locations for XP_006254092.1

    UniProtKB/TrEMBL
    A0A8I6A8S3
    Conserved Domains (6) summary
    smart00153
    Location:2173 → 2208
    VHP; Villin headpiece domain
    cd11280
    Location:1557 → 1657
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1873 → 1978
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1436 → 1532
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1740 → 1853
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1995 → 2117
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  2. XM_063276626.1 → XP_063132696.1  supervillin isoform X8

    UniProtKB/TrEMBL
    A0A8I6A8S3

  3. XM_006254031.5 → XP_006254093.1  supervillin isoform X8

    See identical proteins and their annotated locations for XP_006254093.1

    UniProtKB/TrEMBL
    A0A8I6A8S3
    Conserved Domains (6) summary
    smart00153
    Location:2173 → 2208
    VHP; Villin headpiece domain
    cd11280
    Location:1557 → 1657
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1873 → 1978
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1436 → 1532
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1740 → 1853
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1995 → 2117
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  4. XM_017600627.3 → XP_017456116.1  supervillin isoform X18

    UniProtKB/TrEMBL
    A0A8I6AHH0, D3ZEZ9
    Related
    ENSRNOP00000092895.1, ENSRNOT00000095281.2
    Conserved Domains (6) summary
    smart00153
    Location:1731 → 1766
    VHP; Villin headpiece domain
    cd11280
    Location:1115 → 1215
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1431 → 1536
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:994 → 1090
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1298 → 1411
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1553 → 1675
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  5. XM_063276628.1 → XP_063132698.1  supervillin isoform X16

    UniProtKB/TrEMBL
    D3ZEZ9

  6. XM_017600626.3 → XP_017456115.1  supervillin isoform X17

    UniProtKB/TrEMBL
    D3ZEZ9

  7. XM_017600625.3 → XP_017456114.1  supervillin isoform X15

    UniProtKB/TrEMBL
    D3ZEZ9
    Conserved Domains (6) summary
    smart00153
    Location:1805 → 1840
    VHP; Villin headpiece domain
    cd11280
    Location:1189 → 1289
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1505 → 1610
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1068 → 1164
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1372 → 1485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1627 → 1749
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  8. XM_039095919.2 → XP_038951847.1  supervillin isoform X14

    UniProtKB/TrEMBL
    D3ZEZ9
    Conserved Domains (6) summary
    smart00153
    Location:1832 → 1867
    VHP; Villin headpiece domain
    cd11280
    Location:1216 → 1316
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1532 → 1637
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1095 → 1191
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1399 → 1512
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1654 → 1776
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  9. XM_017600623.3 → XP_017456112.1  supervillin isoform X12

    UniProtKB/TrEMBL
    D3ZEZ9

  10. XM_039095918.2 → XP_038951846.1  supervillin isoform X11

    UniProtKB/TrEMBL
    D3ZEZ9
    Conserved Domains (6) summary
    smart00153
    Location:1887 → 1922
    VHP; Villin headpiece domain
    cd11280
    Location:1271 → 1371
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1587 → 1692
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1150 → 1246
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1454 → 1567
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1709 → 1831
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  11. XM_017600615.3 → XP_017456104.1  supervillin isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8S3, A0A8I6AVE6
    Related
    ENSRNOP00000097742.2, ENSRNOT00000117999.2
    Conserved Domains (6) summary
    smart00153
    Location:2172 → 2207
    VHP; Villin headpiece domain
    cd11280
    Location:1556 → 1656
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1872 → 1977
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1435 → 1531
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1739 → 1852
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1994 → 2116
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  12. XM_017600624.3 → XP_017456113.1  supervillin isoform X13

    UniProtKB/TrEMBL
    D3ZEZ9
    Conserved Domains (6) summary
    smart00153
    Location:1833 → 1868
    VHP; Villin headpiece domain
    cd11280
    Location:1217 → 1317
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1533 → 1638
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1096 → 1192
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1400 → 1513
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1655 → 1777
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  13. XM_017600621.3 → XP_017456110.1  supervillin isoform X10

    UniProtKB/TrEMBL
    D3ZEZ9
    Related
    ENSRNOP00000062712.4, ENSRNOT00000064331.6

  14. XM_063276627.1 → XP_063132697.1  supervillin isoform X9

    UniProtKB/TrEMBL
    A0A8I6AQK9
    Related
    ENSRNOP00000081911.2, ENSRNOT00000108405.2

  15. XM_063276625.1 → XP_063132695.1  supervillin isoform X7

    UniProtKB/TrEMBL
    A0A8I6AQK9

  16. XM_017600619.3 → XP_017456108.1  supervillin isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZKD0
    Conserved Domains (6) summary
    smart00153
    Location:2118 → 2153
    VHP; Villin headpiece domain
    cd11280
    Location:1502 → 1602
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1818 → 1923
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1381 → 1477
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1685 → 1798
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1940 → 2062
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  17. XM_063276624.1 → XP_063132694.1  supervillin isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZT25, A0A8I6A8S3

  18. XM_017600617.3 → XP_017456106.1  supervillin isoform X3

    UniProtKB/TrEMBL
    A0A8I6A8S3
    Conserved Domains (6) summary
    smart00153
    Location:2141 → 2176
    VHP; Villin headpiece domain
    cd11280
    Location:1525 → 1625
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1841 → 1946
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1404 → 1500
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1708 → 1821
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1963 → 2085
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  19. XM_017600618.3 → XP_017456107.1  supervillin isoform X4

    UniProtKB/TrEMBL
    A0A8I6A8S3
    Related
    ENSRNOP00000088108.1, ENSRNOT00000100582.2
    Conserved Domains (6) summary
    smart00153
    Location:2131 → 2166
    VHP; Villin headpiece domain
    cd11280
    Location:1515 → 1615
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1831 → 1936
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1394 → 1490
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1698 → 1811
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1953 → 2075
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  20. XM_017600616.3 → XP_017456105.1  supervillin isoform X2

    UniProtKB/TrEMBL
    A0A8I6A8S3
    Conserved Domains (6) summary
    smart00153
    Location:2147 → 2182
    VHP; Villin headpiece domain
    cd11280
    Location:1531 → 1631
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1847 → 1952
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:1410 → 1506
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:1714 → 1827
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1969 → 2091
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
Nucleotide Protein Strain
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