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Heatr1 HEAT repeat containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361262, updated on 10-Jul-2024

Summary

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Symbol
Heatr1provided by RGD
Full Name
HEAT repeat containing 1provided by RGD
Primary source
RGD:1564769
See related
EnsemblRapid:ENSRNOG00000047594 AllianceGenome:RGD:1564769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Heatr1l1; RGD1564769
Summary
Predicted to enable snoRNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); positive regulation of rRNA processing; and positive regulation of transcription by RNA polymerase I. Predicted to be located in fibrillar center and mitochondrion. Predicted to be part of 90S preribosome; small-subunit processome; and t-UTP complex. Human ortholog(s) of this gene implicated in pancreatic ductal carcinoma. Orthologous to human HEATR1 (HEAT repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 183.9), Thymus (RPKM 109.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Heatr1 in Genome Data Viewer
Location:
17q12.1
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (62745008..62785609, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (58053288..58093895, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (66446135..66488303)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene anillin, actin binding protein-like 1 Neighboring gene galectin 8 Neighboring gene actinin alpha 2 Neighboring gene transfer RNA serine (anticodon AGA) 47 Neighboring gene uncharacterized LOC120097915 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. HEATR1 Negatively Regulates Akt to Help Sensitize Pancreatic Cancer Cells to Chemotherapy. Liu T, et al. Cancer Res, 2016 Feb 1. PMID 26676747, Free PMC Article
  2. Glioma-associated antigen HEATR1 induces functional cytotoxic T lymphocytes in patients with glioma. Wu ZB, et al. J Immunol Res, 2014. PMID 25126583, Free PMC Article
  3. Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. Prieto JL, et al. Genes Dev, 2007 Aug 15. PMID 17699751, Free PMC Article
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of t-UTP complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
HEAT repeat-containing protein 1
Names
HEAT repeat containing 1-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108418.2 → NP_001101888.1  HEAT repeat-containing protein 1

    See identical proteins and their annotated locations for NP_001101888.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6KN33, D3ZL86, M0R3U0
    Related
    ENSRNOP00000064012.3, ENSRNOT00000070825.4
    Conserved Domains (3) summary
    smart01036
    Location:1856 → 2009
    BP28CT; BP28CT (NUC211) domain
    pfam12397
    Location:238 → 354
    U3snoRNP10; U3 small nucleolar RNA-associated protein 10
    sd00044
    Location:1643 → 1678
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    62745008..62785609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600630.3 → XP_017456119.1  HEAT repeat-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A6KN33, D3ZL86, M0R3U0
    Conserved Domains (3) summary
    smart01036
    Location:1856 → 2009
    BP28CT; BP28CT (NUC211) domain
    pfam12397
    Location:238 → 354
    U3snoRNP10; U3 small nucleolar RNA-associated protein 10
    sd00044
    Location:1643 → 1678
    HEAT; HEAT repeat [structural motif]

  2. XM_017600631.3 → XP_017456120.1  HEAT repeat-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A6KN33, D3ZL86, M0R3U0
    Conserved Domains (3) summary
    smart01036
    Location:1856 → 2009
    BP28CT; BP28CT (NUC211) domain
    pfam12397
    Location:238 → 354
    U3snoRNP10; U3 small nucleolar RNA-associated protein 10
    sd00044
    Location:1643 → 1678
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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