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Fundc2 FUN14 domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361288, updated on 2-Nov-2024

Summary

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Official Symbol
Fundc2provided by RGD
Official Full Name
FUN14 domain containing 2provided by RGD
Primary source
RGD:1560916
See related
EnsemblRapid:ENSRNOG00000024066 AllianceGenome:RGD:1560916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560916
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in autophagy of mitochondrion; intracellular triglyceride homeostasis; and regulation of platelet activation. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human FUNDC2 (FUN14 domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 236.6), Heart (RPKM 113.8) and 9 other tissues See more
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Genomic context

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See Fundc2 in Genome Data Viewer
Location:
18p13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (142829..155123, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (128473..138232, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (401878..407954)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene vomeronasal 2 receptor, 75 Neighboring gene BRCA1/BRCA2-containing complex, subunit 3, pseudogene 7 Neighboring gene C-X9-C motif containing 4 Neighboring gene mature T-cell proliferation 1 Neighboring gene uncharacterized LOC134482991 Neighboring gene coagulation factor VIII Neighboring gene myotubularin related protein 1 Neighboring gene uncharacterized LOC134482992

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Zhao X, et al. Mol Cell Proteomics, 2011 Jan. PMID 20833797, Free PMC Article
  2. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FUN14 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135757.1 → NP_001129229.1  FUN14 domain-containing protein 2

    See identical proteins and their annotated locations for NP_001129229.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6AFI8
    Related
    ENSRNOP00000091610.2, ENSRNOT00000108744.2
    Conserved Domains (1) summary
    pfam04930
    Location:49 → 137
    FUN14; FUN14 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    142829..155123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096945.2 → XP_038952873.1  FUN14 domain-containing protein 2 isoform X2

    Related
    ENSRNOP00000098724.1, ENSRNOT00000127983.1
    Conserved Domains (1) summary
    pfam04930
    Location:97 → 152
    FUN14; FUN14 family

  2. XM_039096948.2 → XP_038952876.1  FUN14 domain-containing protein 2 isoform X5

    Related
    ENSRNOP00000099877.1, ENSRNOT00000128470.1
    Conserved Domains (1) summary
    pfam04930
    Location:49 → 104
    FUN14; FUN14 family

  3. XM_039096946.1 → XP_038952874.1  FUN14 domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    pfam04930
    Location:81 → 136
    FUN14; FUN14 family

  4. XM_039096944.1 → XP_038952872.1  FUN14 domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    pfam04930
    Location:129 → 184
    FUN14; FUN14 family

  5. XM_017600984.3 → XP_017456473.3  FUN14 domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    D3ZAQ0
    Related
    ENSRNOP00000036105.4, ENSRNOT00000033618.5

  6. XM_063277458.1 → XP_063133528.1  FUN14 domain-containing protein 2 isoform X7

    Related
    ENSRNOP00000108119.1, ENSRNOT00000133332.1

  7. XM_063277459.1 → XP_063133529.1  FUN14 domain-containing protein 2 isoform X8

  8. XM_039096949.2 → XP_038952877.1  FUN14 domain-containing protein 2 isoform X6

    Conserved Domains (1) summary
    pfam04930
    Location:133 → 188
    FUN14; FUN14 family

  9. XM_063277460.1 → XP_063133530.1  FUN14 domain-containing protein 2 isoform X9

    Related
    ENSRNOP00000101715.1, ENSRNOT00000166370.1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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