Paip2 poly(A) binding protein interacting protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Paip2provided by RGD
Official Full Name: poly(A) binding protein interacting protein 2provided by RGD
Primary source: RGD:1359176
See related: EnsemblRapid:ENSRNOG00000019934 AllianceGenome:RGD:1359176
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable mRNA binding activity and translation repressor activity. Predicted to be involved in negative regulation of translational initiation. Predicted to act upstream of or within several processes, including memory; regulation of long-term synaptic potentiation; and spermatogenesis. Predicted to be active in cytoplasm. Orthologous to human PAIP2 (poly(A) binding protein interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 590.5), Muscle (RPKM 477.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (27475278..27492452)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (27199762..27218359)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (28397320..28415911)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

RH137333 (e-PCR)
- UniSTS:219421

AI409047 (e-PCR)
- UniSTS:250161

RH133364 (e-PCR)
- UniSTS:216647

RH129257 (e-PCR)
- UniSTS:212564

D5S2301E (e-PCR)
- UniSTS:154509

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA regulatory element binding translation repressor activity	IEA Inferred from Electronic Annotation more info
enables translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation repressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of translation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polyadenylate-binding protein-interacting protein 2

Names: PABP-interacting protein 2; PAIP-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.