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Atg12 autophagy related 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361321, updated on 2-Nov-2024

Summary

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Official Symbol
Atg12provided by RGD
Official Full Name
autophagy related 12provided by RGD
Primary source
RGD:1306306
See related
EnsemblRapid:ENSRNOG00000000157 AllianceGenome:RGD:1306306
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Apg12l
Summary
Predicted to enable protein tag activity. Predicted to contribute to Atg8-family ligase activity. Involved in autophagy. Part of protein-containing complex. Orthologous to human ATG12 (autophagy related 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 216.0), Brain (RPKM 202.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atg12 in Genome Data Viewer
Location:
18q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (41638841..41649311, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (39452247..39462424, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (40721799..40732143, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 1A Neighboring gene 40S ribosomal protein S23-like Neighboring gene cysteine dioxygenase type 1 Neighboring gene uncharacterized LOC134482941 Neighboring gene adaptor related protein complex 3 subunit sigma 1 Neighboring gene uncharacterized LOC120098117 Neighboring gene laeverin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Long-term androgen excess induces insulin resistance and non-alcoholic fatty liver disease in PCOS-like rats. Cui P, et al. J Steroid Biochem Mol Biol, 2021 Apr. PMID 33513383
  2. miR-23b improves cognitive impairments in traumatic brain injury by targeting ATG12-mediated neuronal autophagy. Sun L, et al. Behav Brain Res, 2018 Mar 15. PMID 27630106
  3. Changes in autophagy after traumatic brain injury. Liu CL, et al. J Cereb Blood Flow Metab, 2008 Apr. PMID 18059433, Free PMC Article
  4. Scanning Electron-Assisted Dielectric Microscopy Reveals Autophagosome Formation by LC3 and ATG12 in Cultured Mammalian Cells. Okada T, et al. Int J Mol Sci, 2021 Feb 12. PMID 33673233, Free PMC Article
  5. The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Fujita N, et al. Mol Biol Cell, 2008 May. PMID 18321988, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long-term androgen excess induces insulin resistance and non-alcoholic fatty liver disease in PCOS-like rats.
    Title: Long-term androgen excess induces insulin resistance and non-alcoholic fatty liver disease in PCOS-like rats.
  2. Scanning Electron-Assisted Dielectric Microscopy Reveals Autophagosome Formation by LC3 and ATG12 in Cultured Mammalian Cells.
    Title: Scanning Electron-Assisted Dielectric Microscopy Reveals Autophagosome Formation by LC3 and ATG12 in Cultured Mammalian Cells.
  3. Study demonstrated that miR-23b expression was significantly downregulated following traumatic brain injury (TBI). In model TBI, overexpression of miR-23b reduced the lesion volume, brain edema and neuronal apoptosis, and improves cognitive dysfunction. miR-23b specifically bound with the 3' UTR of ATG12 mRNA and modulated its translation; suppressed neuronal autophagy by directly targeting ATG12 expression.
    Title: miR-23b improves cognitive impairments in traumatic brain injury by targeting ATG12-mediated neuronal autophagy.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC125080

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to Atg8-family ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of viral translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Atg12-Atg5-Atg16 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Atg12-Atg5-Atg16 complex ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-like protein ATG12
Names
ATG12 autophagy related 12 homolog
autophagy 12-like
autophagy-related protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038495.1 → NP_001033584.1  ubiquitin-like protein ATG12

    See identical proteins and their annotated locations for NP_001033584.1

    Status: PROVISIONAL

    Source sequence(s)
    BC110056
    UniProtKB/Swiss-Prot
    Q2TBJ5, Q5M9F9
    UniProtKB/TrEMBL
    A6IWW9
    Conserved Domains (1) summary
    cd01612
    Location:55 → 140
    Ubl_ATG12; ubiquitin-like (Ubl) domain found in autophagy-related protein 12 (ATG12)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    41638841..41649311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096964.2 → XP_038952892.1  ubiquitin-like protein ATG12 isoform X2

    Conserved Domains (1) summary
    cd01612
    Location:22 → 106
    Ubl_ATG12; ubiquitin-like (Ubl) domain found in autophagy-related protein 12 (ATG12)

  2. XM_039096963.2 → XP_038952891.1  ubiquitin-like protein ATG12 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYH3
    Related
    ENSRNOP00000000170.5, ENSRNOT00000000170.7
    Conserved Domains (1) summary
    cd01612
    Location:47 → 131
    Ubl_ATG12; ubiquitin-like (Ubl) domain found in autophagy-related protein 12 (ATG12)

  3. XM_063277470.1 → XP_063133540.1  ubiquitin-like protein ATG12 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2TBJ5.1 GenPept UniProtKB/Swiss-Prot:Q2TBJ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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