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Hdhd2 haloacid dehalogenase-like hydrolase domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361351, updated on 2-Nov-2024

Summary

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Official Symbol
Hdhd2provided by RGD
Official Full Name
haloacid dehalogenase-like hydrolase domain containing 2provided by RGD
Primary source
RGD:1308579
See related
EnsemblRapid:ENSRNOG00000043171 AllianceGenome:RGD:1308579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ier3ip1; LRRG00122; RGD1308579
Summary
Predicted to enable enzyme binding activity and phosphatase activity. Predicted to be involved in dephosphorylation and protein transport. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human HDHD2 (haloacid dehalogenase like hydrolase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 75.4), Adrenal (RPKM 67.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hdhd2 in Genome Data Viewer
Location:
18q12.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (72763313..72801679)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (70488315..70526471)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (73226630..73278062)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene SKI family transcriptional corepressor 2 Neighboring gene uncharacterized LOC120098312 Neighboring gene uncharacterized LOC134483057 Neighboring gene immediate early response 3 interacting protein 1 Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene protein inhibitor of activated STAT, 2 Neighboring gene uncharacterized LOC102552068 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Two candidate genes for two quantitative trait loci epistatically attenuate hypertension in a novel pathway. Chauvet C, et al. J Hypertens, 2015 Sep. PMID 26103128
  2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  4. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hdhd2 appears to act from upstream in a pathway by regulating Tcof1/treacle possibly at the level of post-translation.
    Title: Two candidate genes for two quantitative trait loci epistatically attenuate hypertension in a novel pathway.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
haloacid dehalogenase-like hydrolase domain-containing protein 2
Names
immediate early response 3-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412497.1 → NP_001399426.1  haloacid dehalogenase-like hydrolase domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q6AYR6
    UniProtKB/TrEMBL
    A6KMT8
    Related
    ENSRNOP00000075095.1, ENSRNOT00000080660.3

  2. NM_001412498.1 → NP_001399427.1  haloacid dehalogenase-like hydrolase domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q6AYR6
    UniProtKB/TrEMBL
    A6KMT8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    72763313..72801679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001014151.2: Suppressed sequence

    Description
    NM_001014151.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYR6.1 GenPept UniProtKB/Swiss-Prot:Q6AYR6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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