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Cpne7 copine 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361433, updated on 2-Nov-2024

Summary

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Official Symbol
Cpne7provided by RGD
Official Full Name
copine 7provided by RGD
Primary source
RGD:1307466
See related
EnsemblRapid:ENSRNOG00000015397 AllianceGenome:RGD:1307466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium-dependent phospholipid binding activity. Predicted to be involved in cellular response to calcium ion. Predicted to be located in cytoplasm and nucleus. Predicted to be active in plasma membrane and synapse. Orthologous to human CPNE7 (copine 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 96.2), Brain (RPKM 57.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cpne7 in Genome Data Viewer
Location:
19q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68072165..68091197)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51164316..51182676)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55929555..55946251)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551789 Neighboring gene SPG7 matrix AAA peptidase subunit, paraplegin Neighboring gene small nucleolar RNA MBII-202 Neighboring gene ribosomal protein L13 Neighboring gene sulfotransferase family 5A, member 1 Neighboring gene uncharacterized LOC120098589 Neighboring gene dipeptidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The second C2-domain of copine-2, copine-6 and copine-7 is responsible for their calcium-dependent membrane association. Perestenko P, et al. FEBS J, 2015 Oct. PMID 26175110
  2. Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting. Perestenko PV, et al. FEBS J, 2010 Dec. PMID 21087455
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The second C2-domain of copine-7 is responsible for calcium-dependent membrane association.
    Title: The second C2-domain of copine-2, copine-6 and copine-7 is responsible for their calcium-dependent membrane association.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
copine-7
Names
copine VII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399095.1 → NP_001386024.1  copine-7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    H1UBN0
    Related
    ENSRNOP00000068558.1, ENSRNOT00000077701.3
    Conserved Domains (3) summary
    cd04047
    Location:153 → 265
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:20 → 138
    C2A_Copine; C2 domain first repeat in Copine
    pfam07002
    Location:324 → 541
    Copine

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    68072165..68091197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278156.1 → XP_063134226.1  copine-7 isoform X2

  2. XM_039097880.2 → XP_038953808.1  copine-7 isoform X1

    UniProtKB/TrEMBL
    A6IZV5, D3ZWR4
    Conserved Domains (3) summary
    cd04047
    Location:77 → 189
    C2B_Copine; C2 domain second repeat in Copine
    pfam07002
    Location:248 → 465
    Copine
    cl14603
    Location:1 → 62
    C2; C2 domain

RNA

  1. XR_005496670.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108454.1: Suppressed sequence

    Description
    NM_001108454.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H1UBN0.1 GenPept UniProtKB/Swiss-Prot:H1UBN0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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