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Ppil4 peptidylprolyl isomerase like 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361449, updated on 2-Nov-2024

Summary

Official Symbol
Ppil4provided by RGD
Official Full Name
peptidylprolyl isomerase like 4provided by RGD
Primary source
RGD:1311051
See related
EnsemblRapid:ENSRNOG00000015552 AllianceGenome:RGD:1311051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human PPIL4 (peptidylprolyl isomerase like 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 95.1), Spleen (RPKM 74.6) and 9 other tissues See more
Orthologs
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Genomic context

See Ppil4 in Genome Data Viewer
Location:
1p13
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (4093956..4126016)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (2273582..2305639)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (1897316..1930311)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glycosylated integral membrane protein 1 Neighboring gene 40S ribosomal protein S20-like Neighboring gene zinc finger CCCH type containing 12D Neighboring gene TGF-beta activated kinase 1/MAP3K7 binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase-like 4
Names
peptidylprolyl isomerase (cyclophilin)-like 4
NP_001381983.1
XP_038936980.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395054.1NP_001381983.1  peptidyl-prolyl cis-trans isomerase-like 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D4AEG3
    Related
    ENSRNOP00000021437.8, ENSRNOT00000021437.9
    Conserved Domains (2) summary
    cd01921
    Location:4161
    cyclophilin_RRM; cyclophilin-type peptidylprolyl cis- trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). This subfamily of the cyclophilin domain family contains a number of eukaryotic cyclophilins having the RRM domain including the ...
    cd12235
    Location:237319
    RRM_PPIL4; RNA recognition motif (RRM) found in peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    4093956..4126016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081052.2XP_038936980.1  peptidyl-prolyl cis-trans isomerase-like 4 isoform X1

    UniProtKB/TrEMBL
    A6JP20
    Conserved Domains (2) summary
    cd01921
    Location:4161
    cyclophilin_RRM; cyclophilin-type peptidylprolyl cis- trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). This subfamily of the cyclophilin domain family contains a number of eukaryotic cyclophilins having the RRM domain including the ...
    cd12235
    Location:237319
    RRM_PPIL4; RNA recognition motif (RRM) found in peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108457.1: Suppressed sequence

    Description
    NM_001108457.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.