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Isoc2b isochorismatase domain containing 2b [ Rattus norvegicus (Norway rat) ]

Gene ID: 361501, updated on 2-Nov-2024

Summary

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Official Symbol
Isoc2bprovided by RGD
Official Full Name
isochorismatase domain containing 2bprovided by RGD
Primary source
RGD:1309062
See related
EnsemblRapid:ENSRNOG00000016829 AllianceGenome:RGD:1309062
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Isoc2; RGD1309062
Summary
Predicted to be involved in protein destabilization. Predicted to be located in mitochondrion and nucleus. Predicted to be active in cytoplasm. Orthologous to human ISOC2 (isochorismatase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 252.4), Liver (RPKM 143.6) and 9 other tissues See more
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Genomic context

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See Isoc2b in Genome Data Viewer
Location:
1q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78001735..78022565)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (68972960..68993760)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72524569..72545331)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene isochorismatase domain containing 2A Neighboring gene ATPase H+ transporting V0 subunit C, pseudogene 2 Neighboring gene shisa family member 7 Neighboring gene uncharacterized LOC134482885

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a. Huang X, et al. Biochem Biophys Res Commun, 2007 Sep 21. PMID 17658461
  2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC105521

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
isochorismatase domain-containing protein 2
Names
isochorismatase domain containing 2
isochorismatase domain-containing protein 2, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008367.1 → NP_001008368.1  isochorismatase domain-containing protein 2

    See identical proteins and their annotated locations for NP_001008368.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085336
    UniProtKB/Swiss-Prot
    Q5U3Z3
    UniProtKB/TrEMBL
    A0A8L2QD03, A6KNP7
    Related
    ENSRNOP00000066553.3, ENSRNOT00000071971.4
    Conserved Domains (1) summary
    cd01012
    Location:18 → 170
    YcaC_related; YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    78001735..78022565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266269.1 → XP_063122339.1  isochorismatase domain-containing protein 2 isoform X5

    Related
    ENSRNOP00000105164.1, ENSRNOT00000148934.1

  2. XM_063266283.1 → XP_063122353.1  isochorismatase domain-containing protein 2 isoform X6

  3. XM_063266268.1 → XP_063122338.1  isochorismatase domain-containing protein 2 isoform X4

  4. XM_063266265.1 → XP_063122335.1  isochorismatase domain-containing protein 2 isoform X2

  5. XM_063266267.1 → XP_063122337.1  isochorismatase domain-containing protein 2 isoform X3

  6. XM_063266264.1 → XP_063122334.1  isochorismatase domain-containing protein 2 isoform X1

    Related
    ENSRNOP00000022621.5, ENSRNOT00000022620.5

RNA

  1. XR_010054069.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U3Z3.1 GenPept UniProtKB/Swiss-Prot:Q5U3Z3

Gene LinkOut

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