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Wtip WT1 interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 361552, updated on 2-Nov-2024

Summary

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Symbol
Wtipprovided by RGD
Full Name
WT1 interacting proteinprovided by RGD
Primary source
RGD:1306411
See related
AllianceGenome:RGD:1306411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306411; AABR07002945.1
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in several processes, including miRNA-mediated gene silencing by inhibition of translation; negative regulation of hippo signaling; and response to hypoxia. Predicted to act upstream of or within miRNA-mediated post-transcriptional gene silencing. Predicted to be located in P-body. Orthologous to human WTIP (WT1 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 91.5), Kidney (RPKM 70.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wtip in Genome Data Viewer
Location:
1q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95868399..95902117, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86731214..86764939, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89966496..89999892, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene karyopherin subunit alpha 3, pseudogene 1 Neighboring gene secretoglobin, family 1B, member 30 Neighboring gene small nucleolar RNA SNORA11 Neighboring gene ubiquitin-like modifier activating enzyme 2 Neighboring gene programmed cell death 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling. Ayyanathan K, et al. Cancer Res, 2007 Oct 1. PMID 17909014
  2. Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Das Thakur M, et al. Curr Biol, 2010 Apr 13. PMID 20303269, Free PMC Article
  3. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Foxler DE, et al. Nat Cell Biol, 2012 Jan 29. PMID 22286099
  4. LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. James V, et al. Proc Natl Acad Sci U S A, 2010 Jul 13. PMID 20616046, Free PMC Article
  5. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA-mediated gene silencing by inhibition of translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Wilms tumor protein 1-interacting protein
Names
Wilms tumor 1 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400841.1 → NP_001387770.1  Wilms tumor protein 1-interacting protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F1LMC1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    95868399..95902117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266515.1 → XP_063122585.1  Wilms tumor protein 1-interacting protein isoform X2

  2. XM_017590047.3 → XP_017445536.1  Wilms tumor protein 1-interacting protein isoform X2

    UniProtKB/TrEMBL
    A6JA84

  3. XM_039100857.2 → XP_038956785.1  Wilms tumor protein 1-interacting protein isoform X1

    Conserved Domains (3) summary
    cd09352
    Location:192 → 245
    LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins
    cd09355
    Location:257 → 309
    LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins
    PRK07003
    Location:23 → 185
    PRK07003; DNA polymerase III subunit gamma/tau

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108196.1: Suppressed sequence

    Description
    NM_001108196.1: This RefSeq was removed because it contains the wrong CDS.
Nucleotide Protein Strain
Heading Accession and Version

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