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Sytl2 synaptotagmin-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361604, updated on 10-Jul-2024

Summary

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Official Symbol
Sytl2provided by RGD
Official Full Name
synaptotagmin-like 2provided by RGD
Primary source
RGD:1307647
See related
EnsemblRapid:ENSRNOG00000030776 AllianceGenome:RGD:1307647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable neurexin family protein binding activity; phosphatase binding activity; and phospholipid binding activity. Predicted to be involved in positive regulation of mucus secretion and vesicle docking involved in exocytosis. Predicted to act upstream of or within protein localization to plasma membrane. Predicted to be located in melanosome and membrane. Predicted to be extrinsic component of plasma membrane. Predicted to be active in exocytic vesicle and plasma membrane. Orthologous to human SYTL2 (synaptotagmin like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 140.6), Lung (RPKM 77.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sytl2 in Genome Data Viewer
Location:
1q32
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (153685403..153791758)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (144272870..144379310)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (154536592..154599515) , (156334298..156440327, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol binding clathrin assembly protein Neighboring gene coiled-coil domain containing 83 Neighboring gene uncharacterized LOC134485150 Neighboring gene coiled-coil domain containing 89 Neighboring gene CREB/ATF bZIP transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain. Yu M, et al. Mol Biol Cell, 2007 Feb. PMID 17182843, Free PMC Article
  2. Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells. Saegusa C, et al. Genes Cells, 2006 Jun. PMID 16716193
  3. A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion. Ménasché G, et al. Blood, 2008 Dec 15. PMID 18812475
  4. Slp2-a controls renal epithelial cell size through regulation of Rap-ezrin signaling independently of Rab27. Yasuda T, et al. J Cell Sci, 2014 Feb 1. PMID 24284068
  5. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. Holt O, et al. Traffic, 2008 Apr. PMID 18266782, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC189337

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables neurexin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mucus secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking involved in exocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in exocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in melanosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
synaptotagmin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108492.2 → NP_001101962.2  synaptotagmin-like protein 2

    Status: VALIDATED

    Source sequence(s)
    CK842035, JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6AM63
    Related
    ENSRNOP00000096638.1, ENSRNOT00000114461.2
    Conserved Domains (5) summary
    cd04020
    Location:1990 → 2146
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:1850 → 1977
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    PTZ00108
    Location:1592 → 1812
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    TIGR00600
    Location:197 → 425
    rad2; DNA excision repair protein (rad2)
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    153685403..153791758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082411.2 → XP_038938339.1  synaptotagmin-like protein 2 isoform X4

    Conserved Domains (4) summary
    cd04020
    Location:1934 → 2090
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:1794 → 1921
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    TIGR00600
    Location:197 → 425
    rad2; DNA excision repair protein (rad2)
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  2. XM_039082407.2 → XP_038938335.1  synaptotagmin-like protein 2 isoform X3

    Conserved Domains (4) summary
    cd04020
    Location:1950 → 2106
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:1810 → 1937
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    TIGR00600
    Location:197 → 425
    rad2; DNA excision repair protein (rad2)
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  3. XM_039082402.2 → XP_038938330.1  synaptotagmin-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y7C8
    Related
    ENSRNOP00000077270.1, ENSRNOT00000103814.2
    Conserved Domains (4) summary
    cd04020
    Location:1974 → 2130
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:1834 → 1961
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    TIGR00600
    Location:197 → 425
    rad2; DNA excision repair protein (rad2)
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  4. XM_008759651.4 → XP_008757873.1  synaptotagmin-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008757873.1

    UniProtKB/TrEMBL
    A0A8I6AM63
    Conserved Domains (5) summary
    cd04020
    Location:1990 → 2146
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:1850 → 1977
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    PTZ00108
    Location:1592 → 1812
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    TIGR00600
    Location:197 → 425
    rad2; DNA excision repair protein (rad2)
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  5. XM_039082420.2 → XP_038938348.1  synaptotagmin-like protein 2 isoform X5

    Conserved Domains (4) summary
    cd04020
    Location:1871 → 2027
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:1731 → 1858
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    TIGR00600
    Location:197 → 425
    rad2; DNA excision repair protein (rad2)
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  6. XM_039082423.2 → XP_038938351.1  synaptotagmin-like protein 2 isoform X6

    Conserved Domains (4) summary
    cd04020
    Location:784 → 940
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:644 → 771
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    TIGR00600
    Location:197 → 547
    rad2; DNA excision repair protein (rad2)
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  7. XM_039082431.2 → XP_038938359.1  synaptotagmin-like protein 2 isoform X8

    Related
    ENSRNOP00000110457.1, ENSRNOT00000137733.1
    Conserved Domains (4) summary
    cd04020
    Location:744 → 900
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:604 → 731
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    TIGR00600
    Location:197 → 547
    rad2; DNA excision repair protein (rad2)
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  8. XM_039082427.2 → XP_038938355.1  synaptotagmin-like protein 2 isoform X7

    Conserved Domains (4) summary
    cd04020
    Location:768 → 924
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:628 → 755
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    TIGR00600
    Location:197 → 572
    rad2; DNA excision repair protein (rad2)
    cl22851
    Location:5 → 41
    PHD_SF; PHD finger superfamily

  9. XM_063267042.1 → XP_063123112.1  synaptotagmin-like protein 2 isoform X8

  10. XM_063267036.1 → XP_063123106.1  synaptotagmin-like protein 2 isoform X7

  11. XM_063267027.1 → XP_063123097.1  synaptotagmin-like protein 2 isoform X6

    Related
    ENSRNOP00000103847.1, ENSRNOT00000153378.1

  12. XM_063267013.1 → XP_063123083.1  synaptotagmin-like protein 2 isoform X3

    Related
    ENSRNOP00000108929.1, ENSRNOT00000163984.1

  13. XM_063266999.1 → XP_063123069.1  synaptotagmin-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y7C8
Nucleotide Protein Strain
Heading Accession and Version

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