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P4ha3 prolyl 4-hydroxylase subunit alpha 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361612, updated on 2-Nov-2024

Summary

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Official Symbol
P4ha3provided by RGD
Official Full Name
prolyl 4-hydroxylase subunit alpha 3provided by RGD
Primary source
RGD:735150
See related
EnsemblRapid:ENSRNOG00000017118 AllianceGenome:RGD:735150
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables procollagen-proline 4-dioxygenase activity. Predicted to be involved in collagen fibril organization. Predicted to be located in endoplasmic reticulum lumen. Predicted to be part of procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 48.6), Thymus (RPKM 34.3) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See P4ha3 in Genome Data Viewer
Location:
1q32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164040852..164075922)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154628723..154663779)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165295835..165330922)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100912071 Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 3 Neighboring gene phosphoglucomutase 2-like 1 Neighboring gene protein phosphatase methylesterase 1 Neighboring gene uncharacterized LOC120099892 Neighboring gene C2 domain containing 3 centriole elongation regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme. Kukkola L, et al. J Biol Chem, 2003 Nov 28. PMID 14500733
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of collagen prolyl 4-hydroxylase isoenzyme 3, its expression and catalytic properties
    Title: Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-proline 4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables procollagen-proline 4-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-proline 4-dioxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen fibril organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
part_of procollagen-proline 4-dioxygenase complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
prolyl 4-hydroxylase subunit alpha-3
Names
4-PH alpha-3
collagen prolyl 4-hydroxylase alpha III subunit
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3
prolyl 4-hydroxylase, alpha polypeptide III
NP_942070.1
XP_038938408.1
XP_063123235.1
XP_063123241.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198775.1 → NP_942070.1  prolyl 4-hydroxylase subunit alpha-3 precursor

    See identical proteins and their annotated locations for NP_942070.1

    Status: PROVISIONAL

    Source sequence(s)
    AY313450
    UniProtKB/Swiss-Prot
    Q6W3E9
    UniProtKB/TrEMBL
    F1LQ79
    Conserved Domains (2) summary
    smart00702
    Location:356 → 528
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:33 → 159
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    164040852..164075922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267171.1 → XP_063123241.1  prolyl 4-hydroxylase subunit alpha-3 isoform X3

    Related
    ENSRNOP00000094149.1, ENSRNOT00000096221.2

  2. XM_039082480.2 → XP_038938408.1  prolyl 4-hydroxylase subunit alpha-3 isoform X1

    UniProtKB/TrEMBL
    F1LQ79
    Related
    ENSRNOP00000049901.3, ENSRNOT00000046943.4
    Conserved Domains (2) summary
    smart00702
    Location:356 → 478
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:34 → 108
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  3. XM_063267165.1 → XP_063123235.1  prolyl 4-hydroxylase subunit alpha-3 isoform X2

    Related
    ENSRNOP00000106965.1, ENSRNOT00000157481.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6W3E9.1 GenPept UniProtKB/Swiss-Prot:Q6W3E9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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